960化工网/ 文献/ 论文详情

Degradation behavior and biosafety studies of the mPEG–PLGA–PLL copolymer†

Ying Sun,Jun Cao,Yourong Duan
Physical Chemistry Chemical Physics Pub Date : 2016/3/29 0:00:00 , DOI:10.1039/C6CP00767H
Abstract

In a previous study, a novel biodegradable multiblock copolymer, monomethoxy(poly-ethylene glycol)–poly(D,L-lactide-co-glycolide)–poly(L-lysine) (PEAL), was developed as a new drug carrier material. It is imperative to study the biocompatibility and degradation behavior of PEAL to pave the way for clinical applications. Here, we systematically demonstrated that the PEAL copolymer has the appropriate hydrophilicity and biosafety. The degradation rate of the PEAL films was obtained by observing changes in mass, molecular weight (Mw), Mw distribution and degradation products. The degradation rate was observed to have a highly positive correlation with the pH of the medium and negative correlation with the ratio of lactic acid to glycolic acid (LA/GA). Cytotoxicity tests indicated that the degradation products of the copolymer were non-toxic to cells. In zebrafish embryos, the PEAL nanoparticles had no obvious impact on heart rate, production of reactive oxygen species, mortality, or cell apoptosis, and they were observed to have a long circulation time. Therefore, the PEAL copolymer has great potential for use as a drug carrier material.

Graphical abstract: Degradation behavior and biosafety studies of the mPEG–PLGA–PLL copolymer
引用文献
相关CAS号
推荐文献
微信二维码
  • 微信公众号二维码
  • 关注官方微信公众号
  • 微信二维码
  • 微信扫码联系客服
平台客服