规格 | 1 mg |
数量 | 货期:1-2天 |
保存条件 | Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month. |
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MCE 国际站:ARL67156 triethylamine
产品活性:ARL67156 (FPL 67156) triethylamine 是一种 ecto-ATPase 抑制剂。ARL67156 triethylamine 是竞争性 NTPDase1 (CD39),NTPDase3 和 NPP1 抑制剂,Ki 分别为 11,18 和 12 μM。ARL67156 triethylamine 可用于钙化性主动脉瓣疾病、哮喘等疾病的研究。
研究领域:Metabolic Enzyme/Protease
作用靶点:Phosphatase
In Vitro: ARL67156 triethylamine (1-100 μM) potentiates neurogenic contractions in a concentration-dependent manner.
ARL67156 triethylamine (10 μg/mL, 24 h) increases the surface expression of CXCR3 on ATP-treated HMC-1 cells.
ARL67156 triethylamine (30 μM, 5s) potentiates the norepinephrine release promoted by ATP in guinea pig heart synaptosomes.
ARL67156 triethylamine (100 μM, 4h) significantly decreases HIV-1replication in macrophages.
In Vivo: ARL67156 triethylamine (1.1 μg/kg/day, administered with osmotic pumps implanted subcutaneously, for 28 days) prevents the development of calcific aortic valve disease in Warfarin (HY-B0687)-treated rats.
ARL67156 triethylamine (intraperitoneal injection, 2 mg/kg) prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP).
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