1. chem960
  2. Literature
  3. Literature Details
Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry†
Berend van der Wildt,Bin Shen,Frederick T. Chin
CHEMICAL COMMUNICATIONSCHEM COMMUN Pub Date : 2019/2/19 0:00:00 , DOI:10.1039/C8CC09661A
Abstract

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

Graphical abstract: Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry
© 2008 - 2024 chem960.com All rights reserved