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- 1236858-52-8
PF-04449613 是一种 PDE9A 的选择性抑制剂，IC50 为 22 nM。PF-04449613 可增强小鼠的运动学习能力。
- (R)-6-(1-(3-Phenoxyazetidin-1-yl)ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
- 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one
- 6-[(1R)-1-(3-Phenoxyazetidin-1-yl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
- PF 4449613
- PF-9613
- FHBANDDJQJAZOQ-CQSZACIVSA-N
- PF-04449613
- 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-
- PF-04449613 >=98% (HPLC)
- CID 137295260
- 1-(oxan-4-yl)-6-[1-(3-phenoxyazetidin-1-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one
- PF 04449613
- Alternative Name: PF 9613
- 1236858-52-8
- PF04449613
- PF-04449613
- 1-(oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-2H-pyrazolo[3,4-d]pyrimidin-4-one
- BCP25929
- InChIKey：FHBANDDJQJAZOQ-CQSZACIVSA-N
- Inchi：1S/C21H25N5O3/c1-14(25-12-17(13-25)29-16-5-3-2-4-6-16)19-23-20-18(21(27)24-19)11-22-26(20)15-7-9-28-10-8-15/h2-6,11,14-15,17H,7-10,12-13H2,1H3,(H,23,24,27)/t14-/m1/s1
- SMILES：C1([C@H](N2CC(OC3=CC=CC=C3)C2)C)NC(=O)C2C=NN(C3CCOCC3)C=2N=1
Computed Properties
- 精确分子量: 395.19573968g/mol
- 氢键供体数量: 1
- 氢键受体数量: 8
- 可旋转化学键数量: 5
- 同位素质量: 395.19573968g/mol
- 重原子数量: 29
- 复杂度: 626
- 同位素原子数量: 0
- 确定原子立构中心数量: 0
- 不确定原子立构中心数量: 1
- 确定化学键立构中心数量: 0
- 不确定化学键立构中心数量: 0
- 共价键单元数量: 1
- 疏水参数计算参考值（XlogP）: 1.6
- 拓扑分子极性表面积: 81Ų
- 危险品运输编号：NONH for all modes of transport
- 储存条件：−20°C
- 1. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
Amadis Chemical Company Limited
Gold Member
Audited SupplierZheJiang，China(CAS:1236858-52-8)PF 04449613
Amadis Chemical Company Limited
Contact & Address Information
网周路99号
Contact: Fred
Phone: 18658880036
Web: https://www.amadischem.com/
Business Type:Manufacturers
1 Main Products Gold Member Audited SupplierZheJiang，ChinaContact Now
| Brand:sigmaaldrich | Supplier:西格玛奥德里奇（上海）贸易有限公司 | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| PZ0349-5MG | 5mg | ¥1463.56 | 18 Sep. 2023 | ||||
| PZ0349-25MG | 25mg | ¥5899.06 | 18 Sep. 2023 | ||||
| Brand:安耐吉 | Supplier:安徽泽生科技有限公司 | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| PZ0349-25mg | ≥98%(HPLC) | 25mg | ￥5899.06 | 15 Sep. 2023 | |||
| PZ0349-5mg | ≥98%(HPLC) | 5mg | ￥1463.57 | 15 Sep. 2023 | |||
| Brand:aladdin | Supplier:上海阿拉丁生化科技股份有限公司 | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| P286852-10mg | ≥98%(HPLC) | 期货 | 10mg | ¥2545.90 | 01 Sep. 2023 | ||
| Brand:trc | Supplier:TRC | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| P294110-1mg | 0.0 | 1mg | $115.00 | 17 May. 2023 | |||
| P294110-5mg | 0.0 | 5mg | $414.00 | 17 May. 2023 | |||
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