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Venetoclax | 1257044-40-8
Product name：Venetoclax
CAS No：1257044-40-8
MF：C45H50N7O7SCl
MW：868.4392
MDL：MFCD23160052
CID：2083391
Venetoclax (abt-199; gdc-0199) is a highly potent, selective and orally effective Bcl-2 inhibitor with a ki less than 0.01 nm Venetoclax can induce autophagy
- ABT-199
- ABT-199 (GDC-0199)
- 2-(1H-Pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(3-nitro-4-((tetrahydro-2H-pyran-4-yl)methy
- 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide (
- 4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
- ABT 199
- ABT-199 API
- Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester
- Venetoclax（ABT-199）
- CS-1155
- GDC0199
- GDC-0199
- UNII-N54AIC43PW
- Venetoclax
- 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-benzamide
- ABT-199 Venetoclax
- MDL：MFCD23160052
- InChIKey：LQBVNQSMGBZMKD-UHFFFAOYSA-N
- Inchi：InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)
- SMILES：O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Computed Properties
- Exact Mass: 867.31800
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 11
- Rotatable Bond Count: 14
- Heavy Atom Count: 61
Experimental Properties
- LogP: 10.91460
- PSA: 186.58000
- Solubility: Insuluble (6.3E-6 g/L) (25 ºC),
- Density: 1.340±0.06 g/cm3 (20 ºC 760 Torr),
- Hazard Statement：H302-H315-H319-H335
- Warning Statement：P261-P305+P351+P338
- Storage Condition：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- Signal Word：Warning
- 1. Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues Hippolyte Paysant,Siham Hedir,Frédéric Justaud,Louis Bastien Weiswald,Assaad Nasr El Dine,Ali Soulieman,Ali Hachem,Nicolas Elie,Emilie Brotin,Christophe Denoyelle,Jér?me Bignon,Fanny Roussi,Marie Jouanne,Olivier Tasseau,Thierry Roisnel,Anne Sophie Voisin-Chiret,René Grée,Nicolas Levoin,Laurent Poulain Org. Biomol. Chem. 2021 19 8968
- 2. Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents Junrong Song,Junjie Lan,Chao Chen,Shengcao Hu,Jialei Song,Wulin Liu,Xueyi Zeng,Huayong Lou,Yaacov Ben-David,Weidong Pan Med. Chem. Commun. 2018 9 1131
- 3. Venetoclax nanomedicine alleviates acute lung injury via increasing neutrophil apoptosis Ruonan Su,Haixia Wang,Chunsheng Xiao,Yu Tao,Mingqiang Li,Zhuanggui Chen Biomater. Sci. 2021 9 4746
- 4. The era of high-quality chemical probes Marco P. Licciardello,Paul Workman RSC Med. Chem. 2022 13 1446
- 5. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
- 6. Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy Duong Nhu,Guillaume Lessene,David C. S. Huang,Christopher J. Burns Med. Chem. Commun. 2016 7 778
- 7. Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry Berend van der Wildt,Bin Shen,Frederick T. Chin Chem. Commun. 2019 55 3124
- 8. PCL–PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems A. Al Samad,A. Bethry,E. Koziolová,M. Netopilík,T. Etrych,Y. Bakkour,J. Coudane,F. El Omar,B. Nottelet J. Mater. Chem. B 2016 4 6228
- 9. Selectivity mechanism of BCL-XL/2 inhibition through in silico investigation Jiasi Luan,Baichun Hu,Shizhun Wang,Haihan Liu,Shuaizhong Lu,Weixia Li,Xizhe Sun,Jiyue Shi,Jian Wang Phys. Chem. Chem. Phys. 2022 24 17105
- 10. Graft copolymers with tunable amphiphilicity tailored for efficient dual drug delivery via encapsulation and pH-sensitive drug conjugation Markéta Bláhová,Eva Randárová,Rafal Konefa?,Benjamin Nottelet,Tomá? Etrych Polym. Chem. 2020 11 4438
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senfeida
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JiangSu，China(CAS:1257044-40-8)ABT-199
senfeida
Contact & Address Information
苏州高新区浒墅关经济技术开发区
Contact: 闵慧萍
Phone: 18651116180
Web: https://senfeida.en.made-in-china.com/
Business Type:Manufacturers
1 Main Products
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JiangSu，ChinaContact Now -
Heyuan Broad Spectrum Biotechnology Co., Ltd
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GuangDong，China(CAS:1257044-40-8)Venetoclax
GP1000010Spot goods/Spot goods/Spot goods98%/98%/98%1kg/5kg/25kgInquiry/Inquiry/Inquiry15 November 2023Heyuan Broad Spectrum Biotechnology Co., Ltd
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GuangDong，ChinaContact Now -
Amadis Chemical Company Limited
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ZheJiang，China(CAS:1257044-40-8)Venetoclax
A850921in Stock/in Stock99%/99%5g/25gInquiry/Inquiry30 August 2024Amadis Chemical Company Limited
Contact & Address Information
网周路99号
Contact: Fred
Phone: 18658880036
Web: https://www.amadischem.com/
Business Type:Manufacturers
2 Main Products
Gold Member
Audited Supplier
ZheJiang，ChinaContact Now
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| Brand:chemenu | Supplier:Chemenu | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| CM149788-100mg | 95+% | 3-4 Weeks | 100mg | $204 | 02 Mar. 2022 | ||
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