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- chem960
- 143664-11-3
Elacridar is an orally active inhibitor of P-glycoprotein (PGP) and breast cancer resistance protein (BCRP) Elacridar can be used to detect the effect of efflux transporters on the distribution of active molecules in the brain and to study cancer
- Elacridar
- N-[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
- N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-Acridinecarboxamide
- GF120918
- GF-120918
- GG918
- GW0918
- GW120918
- Elacridar (GF120918)
- GG 918
- GF 120918
- AK133066
- N488540F94
- Elacridar [INN]
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- s7772
- E1371
- FT-0667834
- N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
- GW-918
- SCHEMBL536983
- UNII-N488540F94
- AS-18773
- Elacridar, >=98% (HPLC)
- N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- HY-50879
- CHEMBL396298
- BCP9000638
- FT-0667833
- 143664-11-3
- J-007851
- R0Z
- N-(4-(2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide
- MLS006010053
- DTXSID90162489
- N-(4-(2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- NS00069563
- BARIUMMETHACRYLATE
- AC-30265
- AKOS016842744
- CS-1112
- 4'-(2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLYL)ETHYL)-5-METHOXY-9-OXO-4-ACRIDANCARBOXANILIDE
- BDBM50206310
- Q27095554
- MFCD00912604
- GG-918
- N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-2-carboxamide
- NCGC00263219-01
- BCP05709
- N-4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl}-9,10-dihydro-5-methoxy-9-oxo-4-acridone carboxamide
- DB04881
- 4-Acridinecarboxamide, N-(4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-
- NCGC00263219-08
- AM84395
- Elacridar
- GF120918
- EX-A2228
- ELACRIDAR [WHO-DD]
- SMR002529556
- GW-120918
- 5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic acid {4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-amide
- CCG-270068
- MDL：MFCD00912604
- InChIKey：OSFCMRGOZNQUSW-UHFFFAOYSA-N
- Inchi：1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
- SMILES：O(C([H])([H])[H])C1=C(C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])N([H])C(C1=C([H])C([H])=C([H])C3C(C4C([H])=C([H])C([H])=C(C=4N([H])C=31)OC([H])([H])[H])=O)=O)C([H])([H])C2([H])[H])OC([H])([H])[H]
Propriedades Computadas
- Massa Exacta: 563.24200
- Contagem de dadores de ligações de hidrogénio: 2
- Contagem de aceitadores de ligações de hidrogénio: 7
- Contagem de Ligações Rotativas: 8
- Massa monoisotópica: 563.242
- Contagem de Átomos Pesados: 42
- Complexidade: 925
- Contagem de átomos isótopos: 0
- Contagem de Estereocentros Átomos Definidos: 0
- Contagem de Estereocentros Átomos Indefinidos: 0
- Contagem de Stereocenters de Obrigações Definidas: 0
- Contagem de Stereocenters Indefined Bond: 0
- Contagem de Unidades Ligadas Covalentemente: 1
- XLogP3: 5.6
- Superfície polar topológica: 89.1
Propriedades Experimentais
- LogP: 5.57110
- PSA: 92.89000
- Índice de Refracção: 1.644
- Ponto de ebulição: 701.6°C at 760 mmHg
- Ponto de Fusão: 216-218°C
- Ponto de Flash: 378.1°C
- Solubilidade: DMSO: soluble2mg/mL (clear solution, warmed)
- Cor/Forma: Yellow solid
- Densidade: 1.264
- RTECS：AR7621300
- WGK Alemanha：3
- Instrução de Segurança：24/25
- Número de transporte de matérias perigosas：NONH for all modes of transport
- Declaração de perigo：H302
- Declaração de Advertência：P280-P305+P351+P338
- Condição de armazenamento：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- Palavra de Sinal：Warning
- 1. Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs Prashant Joshi,Samsher Singh,Abubakar Wani,Sadhana Sharma,Shreyans K. Jain,Baljinder Singh,Bishan D. Gupta,Naresh K. Satti,Surrinder Koul,Inshad A. Khan,Ajay Kumar,Sandip B. Bharate,Ram A. Vishwakarma Med. Chem. Commun. 2014 5 1540
- 2. The holistic 3M modality of drug delivery nanosystems for cancer therapy Jin Sun,Cong Luo,Yongjun Wang,Zhonggui He Nanoscale 2013 5 845
- 3. Homodimers of the antiviral abacavir as modulators of P-glycoprotein transport in cell culture: probing tether length Hilda A. Namanja,Dana Emmert,Christine A. Hrycyna,Jean Chmielewski Med. Chem. Commun. 2013 4 1344
- 4. Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators Elisa Barile,Marianna Borriello,Attilio Di Pietro,Agnès Doreau,Caterina Fattorusso,Ernesto Fattorusso,Virginia Lanzotti Org. Biomol. Chem. 2008 6 1756
- 5. PCL–PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems A. Al Samad,A. Bethry,E. Koziolová,M. Netopilík,T. Etrych,Y. Bakkour,J. Coudane,F. El Omar,B. Nottelet J. Mater. Chem. B 2016 4 6228
- 6. Recent trends in the use of lipidic nanoparticles as pharmaceutical carriers for cancer therapy and diagnostics Samuel V. Mussi,Vladimir P. Torchilin J. Mater. Chem. B 2013 1 5201
- 7. Polymeric nanovesicles as simultaneous delivery platforms with doxorubicin conjugation and elacridar encapsulation for enhanced treatment of multidrug-resistant breast cancer Hong Xiao,Jin He,Xiaoxia Li,Bo Li,Lu Zhang,Yong Wang,Du Cheng,Xintao Shuai J. Mater. Chem. B 2018 6 7521
- 8. Synthesis and P-glycoprotein induction activity of colupulone analogs Jaideep B. Bharate,Yazan S. Batarseh,Abubakar Wani,Sadhana Sharma,Ram A. Vishwakarma,Amal Kaddoumi,Ajay Kumar,Sandip B. Bharate Org. Biomol. Chem. 2015 13 5488
- 9. Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks Rui Xue Zhang,Taksim Ahmed,Lily Yi Li,Jason Li,Azhar Z. Abbasi,Xiao Yu Wu Nanoscale 2017 9 1334
- 10. Lipid-coated polymeric nanoparticles for cancer drug delivery Sangeetha Krishnamurthy,Rajendran Vaiyapuri,Liangfang Zhang,Juliana M. Chan Biomater. Sci. 2015 3 923
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Amadis Chemical Company Limited
Membro Ouro
Fornecedor auditado
ZheJiang，China(CAS:143664-11-3)Elacridar
A855879in Stock/in Stock/in Stock99%/99%/99%1g/250mg/100mgInquérito/Inquérito/Inquérito30 August 2024Amadis Chemical Company Limited
Contacto & Informações do Endereço
网周路99号
Contacto: Fred
Telefone: 18658880036
Web: https://www.amadischem.com/
Tipo de Negócio:Manufacturers
3 Principais produtos
Membro Ouro
Fornecedor auditado
ZheJiang，ChinaContato Agora
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| Marca:abcr | Fornecedor:abcr | ||||||
|---|---|---|---|---|---|---|---|
| Não. | Pureza | Existência | Especificação | Preço | Tempo de actualização | operar | |
| AB436289-250mg | 95% | 250mg | €641.70 | 06 Jun. 2024 | |||
| AB436289-250 mg | 95% | 250MG | €641.70 | 18 Jul. 2023 | |||
| Marca:sigmaaldrich | Fornecedor:西格玛奥德里奇（上海）贸易有限公司 | ||||||
|---|---|---|---|---|---|---|---|
| Não. | Pureza | Existência | Especificação | Preço | Tempo de actualização | operar | |
| SML0486-50MG | 50mg | ¥7283.06 | 29 Sep. 2023 | ||||
| SML0486-10MG | 10mg | ¥1801.12 | 29 Sep. 2023 | ||||
| Marca:Acmec | Fornecedor:上海吉至生化科技有限公司 | ||||||
|---|---|---|---|---|---|---|---|
| Não. | Pureza | Existência | Especificação | Preço | Tempo de actualização | operar | |
| E33100-100mg | 98% | 现货 | 100mg | ¥1031.0 | 08 Sep. 2023 | ||
| Marca:chemenu | Fornecedor:Chemenu | ||||||
|---|---|---|---|---|---|---|---|
| Não. | Pureza | Existência | Especificação | Preço | Tempo de actualização | operar | |
| CM145777-250mg | 98% | 1-2 Weeks | 250mg | $449 | 05 Aug. 2021 | ||
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