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- 143664-11-3
Elacridar | 143664-11-3
Nombre del producto：Elacridar
Número CAS：143664-11-3
MF：C34H33N3O5
Megavatios：563.6429
MDL：MFCD00912604
Zona central de información：64787
Pubchem ID：329825437
Elacridar is an orally active inhibitor of P-glycoprotein (PGP) and breast cancer resistance protein (BCRP) Elacridar can be used to detect the effect of efflux transporters on the distribution of active molecules in the brain and to study cancer
- Elacridar
- N-[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
- N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-Acridinecarboxamide
- GF120918
- GF-120918
- GG918
- GW0918
- GW120918
- Elacridar (GF120918)
- GG 918
- GF 120918
- AK133066
- N488540F94
- Elacridar [INN]
- N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- s7772
- E1371
- FT-0667834
- N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
- GW-918
- SCHEMBL536983
- UNII-N488540F94
- AS-18773
- Elacridar, >=98% (HPLC)
- N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamide
- HY-50879
- CHEMBL396298
- BCP9000638
- FT-0667833
- 143664-11-3
- J-007851
- R0Z
- N-(4-(2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide
- MLS006010053
- DTXSID90162489
- N-(4-(2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide
- NS00069563
- BARIUMMETHACRYLATE
- AC-30265
- AKOS016842744
- CS-1112
- 4'-(2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLYL)ETHYL)-5-METHOXY-9-OXO-4-ACRIDANCARBOXANILIDE
- BDBM50206310
- Q27095554
- MFCD00912604
- GG-918
- N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-2-carboxamide
- NCGC00263219-01
- BCP05709
- N-4-[2-(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl}-9,10-dihydro-5-methoxy-9-oxo-4-acridone carboxamide
- DB04881
- 4-Acridinecarboxamide, N-(4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)-9,10-dihydro-5-methoxy-9-oxo-
- NCGC00263219-08
- AM84395
- Elacridar
- GF120918
- EX-A2228
- ELACRIDAR [WHO-DD]
- SMR002529556
- GW-120918
- 5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic acid {4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-amide
- CCG-270068
- MDL：MFCD00912604
- InChIKey：OSFCMRGOZNQUSW-UHFFFAOYSA-N
- Inchi：1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38)
- SMILES：O(C([H])([H])[H])C1=C(C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])N([H])C(C1=C([H])C([H])=C([H])C3C(C4C([H])=C([H])C([H])=C(C=4N([H])C=31)OC([H])([H])[H])=O)=O)C([H])([H])C2([H])[H])OC([H])([H])[H]
Atributos calculados
- Calidad precisa: 563.24200
- Recuento de donantes vinculados al hidrógeno: 2
- Recuento de receptores de enlace de hidrógeno: 7
- Cuenta de enlace giratorio: 8
- Masa isotópica única: 563.242
- Recuento de átomos pesados: 42
- Complejidad: 925
- Recuento atómico isotópico: 0
- Recuento del Centro estereoscópico atómico definido: 0
- Recuento de centros estereoscópicos atómicos indefinidos: 0
- Recuento de centros tridimensionales de bonos fijos: 0
- Conteo indefinido de centros tridimensionales de Bond: 0
- Recuento de unidades de unión covalente: 1
- Xlogp3: 5.6
- Superficie del Polo topológico: 89.1
Propiedades experimentales
- Logp: 5.57110
- PSA: 92.89000
- índice de refracción: 1.644
- Punto de ebullición: 701.6°C at 760 mmHg
- Punto de fusión: 216-218°C
- Punto de inflamación: 378.1°C
- Disolución: DMSO: soluble2mg/mL (clear solution, warmed)
- Color / forma: Yellow solid
- Denso: 1.264
- Rtecs：AR7621300
- Wgk Alemania：3
- Instrucciones de Seguridad：24/25
- Número de transporte de mercancías peligrosas：NONH for all modes of transport
- Instrucciones de peligro：H302
- Declaración de advertencia：P280-P305+P351+P338
- Condiciones de almacenamiento：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- Palabra de señal：Warning
- 1. Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugs Prashant Joshi,Samsher Singh,Abubakar Wani,Sadhana Sharma,Shreyans K. Jain,Baljinder Singh,Bishan D. Gupta,Naresh K. Satti,Surrinder Koul,Inshad A. Khan,Ajay Kumar,Sandip B. Bharate,Ram A. Vishwakarma Med. Chem. Commun. 2014 5 1540
- 2. The holistic 3M modality of drug delivery nanosystems for cancer therapy Jin Sun,Cong Luo,Yongjun Wang,Zhonggui He Nanoscale 2013 5 845
- 3. Homodimers of the antiviral abacavir as modulators of P-glycoprotein transport in cell culture: probing tether length Hilda A. Namanja,Dana Emmert,Christine A. Hrycyna,Jean Chmielewski Med. Chem. Commun. 2013 4 1344
- 4. Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators Elisa Barile,Marianna Borriello,Attilio Di Pietro,Agnès Doreau,Caterina Fattorusso,Ernesto Fattorusso,Virginia Lanzotti Org. Biomol. Chem. 2008 6 1756
- 5. PCL–PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems A. Al Samad,A. Bethry,E. Koziolová,M. Netopilík,T. Etrych,Y. Bakkour,J. Coudane,F. El Omar,B. Nottelet J. Mater. Chem. B 2016 4 6228
- 6. Recent trends in the use of lipidic nanoparticles as pharmaceutical carriers for cancer therapy and diagnostics Samuel V. Mussi,Vladimir P. Torchilin J. Mater. Chem. B 2013 1 5201
- 7. Polymeric nanovesicles as simultaneous delivery platforms with doxorubicin conjugation and elacridar encapsulation for enhanced treatment of multidrug-resistant breast cancer Hong Xiao,Jin He,Xiaoxia Li,Bo Li,Lu Zhang,Yong Wang,Du Cheng,Xintao Shuai J. Mater. Chem. B 2018 6 7521
- 8. Synthesis and P-glycoprotein induction activity of colupulone analogs Jaideep B. Bharate,Yazan S. Batarseh,Abubakar Wani,Sadhana Sharma,Ram A. Vishwakarma,Amal Kaddoumi,Ajay Kumar,Sandip B. Bharate Org. Biomol. Chem. 2015 13 5488
- 9. Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks Rui Xue Zhang,Taksim Ahmed,Lily Yi Li,Jason Li,Azhar Z. Abbasi,Xiao Yu Wu Nanoscale 2017 9 1334
- 10. Lipid-coated polymeric nanoparticles for cancer drug delivery Sangeetha Krishnamurthy,Rajendran Vaiyapuri,Liangfang Zhang,Juliana M. Chan Biomater. Sci. 2015 3 923
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Amadis Chemical Company Limited
Miembros de la medalla de oro
Proveedores auditados
ZheJiang，China(CAS:143664-11-3)Elacridar
A855879in Stock/in Stock/in Stock99%/99%/99%1g/250mg/100mgInvestigación/Investigación/Investigación30 August 2024Amadis Chemical Company Limited
Contacto & Información de dirección
网周路99号
Contacto: Fred
Teléfono: 18658880036
Malla: https://www.amadischem.com/
Tipo de negocio:Manufacturers
3 Principales productos
Miembros de la medalla de oro
Proveedores auditados
ZheJiang，ChinaContacto inmediato
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| Marca:Acmec | Proveedores:上海吉至生化科技有限公司 | ||||||
|---|---|---|---|---|---|---|---|
| No, No.. | Pureza | Acciones | Especificaciones | Precio | Tiempo de actualización | Funcionamiento | |
| E33100-100mg | 98% | 现货 | 100mg | ¥1031.0 | 08 Sep. 2023 | ||
| Marca:chemenu | Proveedores:Chemenu | ||||||
|---|---|---|---|---|---|---|---|
| No, No.. | Pureza | Acciones | Especificaciones | Precio | Tiempo de actualización | Funcionamiento | |
| CM145777-250mg | 98% | 1-2 Weeks | 250mg | $449 | 05 Aug. 2021 | ||
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