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- 50-35-1
Thalidomide can inhibit cereblon (part of the cullin-4 E3 ubiquitin ligase complex cul4-rbx1-ddb1), with a Kd value of about 250 nm, and has immunomodulatory \ anti-inflammatory \ anti-tumor effects Thalidomide can be used as a molecular glue to enhance the substrate
- 2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione
- (+/-)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE
- 2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISO-INDOLE-1,3(2H)-DIONE
- 3-PHTHALIMIDOGLUTARIMIDE
- ALPHA-PHTHALIMIDOGLUTARIMIDE
- (+/-)-N-(2,6-DIOXO-3-PIPERIDINYL)PHTHALIMIDE
- (+/-)-THALIDOMIDE
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
- 2-(2,6-dioxo-3-piperidinyl)-1h-isoindole-3(2h)-dione
- 2,6-Dioxo-3-phthalimidopiperidine
- 2-phthalimido-glutarimid
- Algosediv
- alpha-(N-Phthalimido)glutarimide
- alpha-N-Phthalylglutaramide
- asidon3
- Asmadion
- Asmaval
- Thalidomide
- (±)-Thalidomide
- (±)-Thalidomide ( alpha-phthalimidoglutarimide, N-phthaloylglutamimide, N-phthalylglutamic acid imide,Synovir®, Thalomid®, Contergan®)
- N-(2,6-Dioxopiperidin-3-yl)phthalimide
- MacConkey Broth Medium
- (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- N-(2,6-Dioxo-3-piperidinyl)phthalimide
- 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- Thalomid
- Sedoval
- Corronarobetin
- Psychotablets
- Theophilcholine
- Psycholiquid
- Tensival
- Talismol
- Softenil
- Quetimid
- Nevrodyn
- Neurosedin
- Nerosedyn
- Glutanon
- Gastrinide
- Enterosediv
- Contergan
- Calmorex
- Telargean
- Talargan
- Profarmil
- Neosydyn
- Hippuzon
- Ectiluran
- Thalinette
- Softenon
- Shinnibrol
- Sedisperil
- Polygripan
- Pantosediv
- Neufatin
- Neosedyn
- Valgraine
- Sedimide
- Sandormin
- Quietoplex
- Noctosediv
- Neurosedym
- N
- MDL：MFCD00153873
- InChIKey：UEJJHQNACJXSKW-UHFFFAOYSA-N
- Inchi：1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
- SMILES：O=C1C([H])(C([H])([H])C([H])([H])C(N1[H])=O)N1C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)=O
Computed Properties
- Exact Mass: 258.06400
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 4
- Rotatable Bond Count: 1
- Monoisotopic Mass: 258.064
- Heavy Atom Count: 19
- Complexity: 449
- Isotope Atom Count: 0
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Covalently-Bonded Unit Count: 1
- XLogP3: 0.3
- Tautomer Count: 8
- Surface Charge: 0
- Topological Polar Surface Area: 83.6
Experimental Properties
- LogP: 0.35450
- PSA: 83.55000
- Merck: 9255
- Refractive Index: 1.646
- Water Partition Coefficient: <0.1 g/100 mL at 22 ºC
- Boiling Point: 509.7°C at 760 mmHg
- Melting Point: 269-271°C
- Flash Point: 262.1°C
- Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.6 mg/mL
- Color/Form: White solid
- Stability/Shelf Life: Stable. Combustible. Incompatible with strong oxidizing agents.
- Solubility: It is slightly soluble in water (<0.1 g/100 ml at 22 º C), ethanol and acetone, but insoluble in ether and chloroform. 45% (w/v) AQ 2-hydroxypropyl- β- Cyclodextrin: 0.6 mg/ml
- λmax: 300(lit.)
- Density: 1.503 g/cm3
-
Symbol:
GHS06
GHS08 
- RTECS：TI4375000
- WGK Germany：3
- Safety Term：6.1(b)
- Safety Instruction：S53-S22-S26-S36/37/39-S45
- Packing Group：III
- Packing Group：III
- Risk Phrases：R46; R61; R21; R25; R62
- Hazard Level：6.1(b)
-
Dangerous goods sign：
T
- Hazardous Material transportation number：UN 2811 6.1/PG 3
- Hazard Statement：H301-H312-H361
- Warning Statement：P280-P301 + P310
- Prompt：dangerous
- Storage Condition：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- PackingGroup：III
- Hazard Category Code：61-22
- Signal Word：Danger
- HazardClass：6.1
- HS CODE：2925190090
- Customs Data：
China Customs Code:
2925190090Overview:
2925190090 Other imides and their derivative salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
- 1. Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents Anas Ramadan Kotb,Abdallah E. Abdallah,Hazem Elkady,Ibrahim H. Eissa,Mohammed S. Taghour,Dina Abed Bakhotmah,Tamer M. Abdelghany,Mohamed Ayman El-Zahabi RSC Adv. 2023 13 10488
- 2. Quantitative determination of the enantiomeric composition of thalidomide solutions by electrospray ionization tandem mass spectrometry Daniella V. Augusti,Rodinei Augusti,Fernando Carazza,R. Graham Cooks tandem mass spectrometry. Daniella V. Augusti Rodinei Augusti Fernando Carazza R. Graham Cooks Chem. Commun. 2002 2242
- 3. Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways Tomoyo Sakata,James K. Chen Chem. Soc. Rev. 2011 40 4318
- 4. Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: mechanistic rationale and implications Mayaka Maeno,Etsuko Tokunaga,Takeshi Yamamoto,Toshiya Suzuki,Yoshiyuki Ogino,Emi Ito,Motoo Shiro,Toru Asahi,Norio Shibata Chem. Sci. 2015 6 1043
- 5. Enantioselective synthetic thalidomide receptors based upon DNA binding motifs Jenny P. Rosengren,Jesper G. Karlsson,Ian A. Nicholls Org. Biomol. Chem. 2004 2 3374
- 6. Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents Anas Ramadan Kotb,Dina A. Bakhotmah,Abdallah E. Abdallah,Hazem Elkady,Mohammed S. Taghour,Ibrahim. H. Eissa,Mohamed Ayman El-Zahabi RSC Adv. 2022 12 33525
- 7. Thalidomide-type teratogenicity: structure–activity relationships for congeners R. L. Smith,S. C. Mitchell Toxicol. Res. 2018 7 1036
- 8. Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders Junichi Yamamoto,Takumi Ito,Yuki Yamaguchi,Hiroshi Handa Chem. Soc. Rev. 2022 51 6234
- 9. Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue Scott G. Stewart,Carlos J. Braun,Marta E. Polomska,Mahdad Karimi,Lawrence J. Abraham,Keith A. Stubbs Org. Biomol. Chem. 2010 8 4059
- 10. Novel thalidomide analogues with potent NFκB and TNF expression inhibition Sing Yee Yeung,Sven Kampmann,Keith A. Stubbs,Brian W. Skelton,Belinda J. Kaskow,Lawrence J. Abraham,Scott G. Stewart Med. Chem. Commun. 2011 2 1073
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2-Hydroxyisoindoline-1,3-dione CAS No.: 524-38-9 -
2-Methylisoindoline-1,3-dione CAS No.: 550-44-7 -
5-Aminoisoindoline-1,3-dione CAS No.: 3676-85-5 -
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senfeida
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senfeida
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Amadis Chemical Company Limited
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ZheJiang，China(CAS:50-35-1)Thalidomide
Amadis Chemical Company Limited
Contact & Address Information
网周路99号
Contact: Fred
Phone: 18658880036
Web: https://www.amadischem.com/
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ZheJiang，ChinaContact Now
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>98% >98.0%(HPLC)(N) ≥98% ≥99% 95% 95%+ 95.0% 97% 98% 98.0%(LC&N) 98.88% 98+% 99% 99.88% 99.89% 99.92% 99.98%+ multiple choice
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0.0 1 1~2天 3-4 weeks 5-7个工作日 9 Available Now! In China Stock in stock In Stock USA In-stock TBC Trace Amount Usually 10-15 days 待询 河北: 2 河北:2 河北:3 美国:0/中国:0 美国:0/中国:1 美国:Back order/中国:Back order, >=4 weeks 上海:/天津:/日本:13 上海：> 10/安徽：8/武汉：2/成都：> 10/天津:/深圳: 上海:1/天津:1/日本:8 上海：9/安徽：7/武汉：> 10/成都：> 10/天津:/深圳: 上海现货 现货 中国:11/USA:2 中国:12/USA:14 中国:12/USA:2 中国:24/USA:7 中国:3/USA:2 中国:4/USA:8 中国:5/USA:1+ multiple choice
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| Brand:南京试剂 | Supplier:南京化学试剂股份有限公司 | ||||||
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| No. | Purity | Stock | Specification | Price | update time | operate | |
| C0422159431-250mg | 250mg | ¥ 106.0 | 21 May. 2024 | ||||
| Brand:selleck | Supplier:Selleck中国 | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| S1193-200mg | 99.98% | 现货 | 200mg | ¥658.37 | 07 Nov. 2023 | ||
| S1193-1g | 99.98% | 现货 | 1g | ¥2211.3 | 07 Nov. 2023 | ||
| Brand:tenovapharma | Supplier:Tenova Pharmaceuticals | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| T55066-5mg | 98% | Available Now! | 5mg | $90.00 | 21 Sep. 2023 | ||
| Brand:安捷凯 | Supplier:武汉安捷凯生物医药科技有限公司 | ||||||
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| No. | Purity | Stock | Specification | Price | update time | operate | |
| ajci18350-200mg | 98% | 现货 | 200mg | ￥466.00 | 09 Sep. 2023 | ||
| Brand:chemenu | Supplier:Chemenu | ||||||
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| No. | Purity | Stock | Specification | Price | update time | operate | |
| CM110594-500mg | 95%+ | 3-4 weeks | 500mg | $217 | 05 Sep. 2022 | ||
| Brand:dcchemical | Supplier:DC Chemicals | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| DC9009-1 g | >98% | In stock | 1g | $300.0 | 28 Feb. 2022 | ||
| DC9009-1g | >98% | In stock | 1g | $300.0 | 15 Sep. 2023 | ||
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