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- 2044701-99-5
Introduction
Hdac3-in-1 (compound 5) is a potent and selective HDAC3 inhibitor with an IC50 of 5.96 nm
Names and Identifiers
- HDAC3 Inhibitor
- Benzoic acid, 4-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]amino]methyl]-, 2-propylhydrazide
- HDAC3-IN-1
- InChIKey：MHZUZIALEUTHIU-JLHYYAGUSA-N
- Inchi：1S/C20H23N3O2/c1-2-14-22-23-20(25)18-11-8-17(9-12-18)15-21-19(24)13-10-16-6-4-3-5-7-16/h3-13,22H,2,14-15H2,1H3,(H,21,24)(H,23,25)/b13-10+
- SMILES：C(NNCCC)(=O)C1=CC=C(CNC(=O)/C=C/C2=CC=CC=C2)C=C1
Related Literature
- 1. Design, synthesis, and biological evaluation of novel nicotinamide derivatives as potential histone deacetylase-3 inhibitors Mohamed M. S. Hamoud,Sravani Pulya,Nermine A. Osman,Yamini Bobde,Abdalla E. A. Hassan,Hanan A. Abdel-Fattah,Balaram Ghosh,Amany M. Ghanim New J. Chem. 2020 44 9671
- 2. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
- 3. Up-regulation of neprilysin mediates the protection of fructo-oligosaccharides against Alzheimer's disease Sining Wu,Jingzhu Zhang,Congmin Jiang,Sihui Wang,Ran Que,Li An Food Funct. 2020 11 6565
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