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- 1403783-31-2
Nexturastat A | 1403783-31-2
Product name：Nexturastat A
CAS No：1403783-31-2
MF：C19H23N3O3
MW：341.4042
MDL：MFCD28099804
CID：2083584
Nexturastat A is a potent and selective HDAC6 inhibitor Nexturastat a inhibited HDAC6 with an IC50 of 5 nm Nexturastat a can be used in the study of multiple myeloma (mm)
- 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
- Nexturastat A
- NexturastatA
- S7473
- Nexturastat A
- 4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide
- AK175589
- 4-{[butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide
- nexturastat-a
- N4R
- GTPL7504
- AOB6618
- HMS3750M11
- HMS3653J07
- BCP09960
- BDBM50398716
- 2584AH
- SW220090-1
- B3704
- A14032
- Benzamide, 4-[[butyl
- MDL：MFCD28099804
- InChIKey：JZWXMCPARMXZQV-UHFFFAOYSA-N
- Inchi：1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23)
- SMILES：O=C(N([H])C1C([H])=C([H])C([H])=C([H])C=1[H])N(C([H])([H])C1C([H])=C([H])C(C(N([H])O[H])=O)=C([H])C=1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
Computed Properties
- Exact Mass: 341.17400
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 3
- Rotatable Bond Count: 7
- Heavy Atom Count: 25
- Complexity: 416
- Topological Polar Surface Area: 81.7
Experimental Properties
- LogP: 4.04430
- PSA: 85.16000
- Solubility: Very slightly soluble (0.13 g/l) (25 º C),
- Density: 1.228±0.06 g/cm3 (20 ºC 760 Torr),
- Hazard Statement：H302
- Warning Statement：P280-P305+P351+P338
- Storage Condition：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
- Signal Word：Warning
- 1. PROTAC chemical probes for histone deacetylase enzymes Urvashi Patel,Joshua P. Smalley,James T. Hodgkinson RSC Chem. Biol. 2023 4 623
- 2. Chemically induced degradation of epigenetic targets Md Kabir,Xufen Yu,H. ümit Kaniskan,Jian Jin Chem. Soc. Rev. 2023 52 4313
- 3. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
- 4. Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides D. Wutz,D. Gluhacevic,A. Chakrabarti,K. Schmidtkunz,D. Robaa,F. Erdmann,C. Romier,W. Sippl,M. Jung,B. K?nig Org. Biomol. Chem. 2017 15 4882
- 5. Plasticity in designing PROTACs for selective and potent degradation of HDAC6 Haiyan Yang,Wenxing Lv,Ming He,Haiteng Deng,Haitao Li,Wei Wu,Yu Rao Chem. Commun. 2019 55 14848
- 6. Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs Mohd. Muddassir,Kunjal Soni,Chetan B. Sangani,Abdullah Alarifi,Mohd. Afzal,Naaser A. Y. Abduh,Yongtao Duan,Poonam Bhadja RSC Adv. 2021 11 612
- 7. Development of the first non-hydroxamate selective HDAC6 degraders Tim Keuler,Beate K?nig,Nico Bückrei?,Fabian B. Kraft,Philipp K?nig,Linda Sch?ker-Hübner,Christian Steinebach,Gerd Bendas,Michael Gütschow,Finn K. Hansen Chem. Commun. 2022 58 11087
- 8. Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors D. Diedrich,A. Hamacher,C. G. W. Gertzen,L. A. Alves Avelar,G. J. Reiss,T. Kurz,H. Gohlke,M. U. Kassack,F. K. Hansen Chem. Commun. 2016 52 3219
- 9. Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition Yves Depetter,Silke Geurs,Flore Vanden Bussche,Rob De Vreese,Jorick Franceus,Tom Desmet,Olivier De Wever,Matthias D'hooghe Med. Chem. Commun. 2018 9 1011
- 10. Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with DNA damage and apoptosis inducing abilities Ji Liu,Tingting Wang,Xinyang Wang,Lin Luo,Jing Guo,Yanfu Peng,Qibing Xu,Jiefei Miao,Yanan Zhang,Yong Ling Med. Chem. Commun. 2017 8 1213
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Amadis Chemical Company Limited
Gold Member
Audited Supplier
ZheJiang，China(CAS:1403783-31-2)Nexturastat A
A858210in Stock/in Stock/in Stock99%/99%/99%100mg/250mg/1gInquiry/Inquiry/Inquiry30 August 2024Amadis Chemical Company Limited
Contact & Address Information
网周路99号
Contact: Fred
Phone: 18658880036
Web: https://www.amadischem.com/
Business Type:Manufacturers
3 Main Products
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ZheJiang，ChinaContact Now
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0.0 In China Stock in stock In Stock USA In-stock Usually 10 days 上海仓库：现货北方仓库：非现货 上海现货 现货 中国:-/USA:- 中国:0/USA:1 中国:0/USA:2 中国:0/USA:3+ multiple choice
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0.5g 1 mL * 10 mM (in DMSO) 100mg 10g 10mg 10mM (1mL in DMSO) 10mM*1 mL in DMSO 10mM*1mLinDMSO 1g 1mg 250mg 25mg 50mg 5g 5mg+ multiple choice
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1PlusChem A2B Chem LLC Aaron abcr Ambeed Axon Medchem ChemScence DC Chemicals eNovation Chemicals LLC Key Organics Ltd LKT Labs MedChemExpress Selleck中国 TRC 上海吉至生化科技有限公司 上海麦克林生化科技有限公司 上海陶术生物科技有限公司 上海贤鼎生物科技有限公司 圣克鲁斯生物技术 武汉安捷凯生物医药科技有限公司+ multiple choice
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| ajci11770-5mg | 98% | 现货 | 5mg | ￥2234.00 | 09 Sep. 2023 | ||
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| Brand:scbt | Supplier:圣克鲁斯生物技术 | ||||||
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| sc-478176-1 mg | 1mg | ￥2,482.00 | 11 Jul. 2023 | ||||
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| B-QV535-5mg | 98+% | 现货 | 5mg | 3096CNY | 08 May. 2021 | ||
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