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Ricolinostat | 1316214-52-4
Product name：Ricolinostat
CAS No：1316214-52-4
MF：C24H27N5O3
MW：433.5029
MDL：MFCD22666356
CID：839602
Ricolinostat (acy-1215) is a potent and selective HDAC6 inhibitor with an IC50 of 5 nm Acy-1215 also inhibited HDAC1, HDAC2 and HDAC3 with IC50 of 58, 48 and 51 nm, respectively
- Rocilinostat
- ACY-1215
- Rocilinostat (ACY-1215)
- 2-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide
- 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-Pyrimidinecarboxamide
- ACY1215
- ACY1215,Rocilinostat
- N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
- ACY-63
- Ricolinostat
- Ricolinostat [USAN]
- ACY 63
- WKT909C62B
- AK151416
- 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
- Ricolinostat [USAN:INN]
- 5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyami
- MDL：MFCD22666356
- InChIKey：QGZYDVAGYRLSKP-UHFFFAOYSA-N
- Inchi：1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
- SMILES：O=C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(C1C([H])=NC(=NC=1[H])N(C1C([H])=C([H])C([H])=C([H])C=1[H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)N([H])O[H]
Computed Properties
- Exact Mass: 433.21100
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 6
- Rotatable Bond Count: 11
- Heavy Atom Count: 32
- Complexity: 538
- Topological Polar Surface Area: 107
Experimental Properties
- LogP: 5.54720
- PSA: 114.43000
- Solubility: Insuluble (4.3E-3 g/L) (25 ºC),
- Density: 1.239±0.06 g/cm3 (20 ºC 760 Torr),
- Hazard Statement：H302-H315-H319-H335
- Warning Statement：P261-P305+P351+P338
- Storage Condition：4°C, stored under nitrogen
- Signal Word：Warning
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
- 1. Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity Nina Re?ing,Viktoria Marquardt,Christoph G. W. Gertzen,Andrea Sch?ler,Alexander Schramm,Thomas Kurz,Holger Gohlke,Achim Aigner,Marc Remke,Finn K. Hansen Med. Chem. Commun. 2019 10 1109
- 2. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
- 3. Anti-multiple myeloma potential of resynthesized belinostat derivatives: an experimental study on cytotoxic activity, drug combination, and docking studies Hong Phuong Nguyen,Quang De Tran,Cuong Quoc Nguyen,Tran Phuong Hoa,Tran Duy Binh,Huynh Nhu Thao,Bui Thi Buu Hue,Nguyen Trong Tuan,Quang Le Dang,Nguyen Quoc Chau Thanh,Nguyen Van Ky,Minh Quan Pham,Su-Geun Yang RSC Adv. 2022 12 22108
- 4. Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile Christoph Selg,Andrea Sch?ler,Julian Schliehe-Diecks,Maria Hanl,Laura Sinatra,Arndt Borkhardt,Menyhárt B. Sárosi,Sanil Bhatia,Evamarie Hey-Hawkins,Finn K. Hansen Chem. Sci. 2021 12 11873
- 5. Novel histone deacetylase 6 inhibitors using benzimidazole as caps for cancer treatment Phuong Hong Nguyen,Bui Thi Buu Hue,Minh Quan Pham,Tran Phuong Hoa,Quang De Tran,Hosun Jung,Le Trong Hieu,Nguyen Cuong Quoc,Hong Vinh Quang,Nguyen Phu Quy,Hye Jin Yoo,Su-Geun Yang New J. Chem. 2023 47 7622
- 6. Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors D. Diedrich,A. Hamacher,C. G. W. Gertzen,L. A. Alves Avelar,G. J. Reiss,T. Kurz,H. Gohlke,M. U. Kassack,F. K. Hansen Chem. Commun. 2016 52 3219
- 7. In silico design of novel benzohydroxamate-based compounds as inhibitors of histone deacetylase 6 based on 3D-QSAR, molecular docking, and molecular dynamics simulations Han Chu,Qing-xiu He,Juan Wang,Yong Hu,Yuan-qiang Wang,Zhi-hua Lin New J. Chem. 2020 44 21201
- 8. Next-generation of selective histone deacetylase inhibitors Feifei Yang,Na Zhao,Di Ge,Yihua Chen RSC Adv. 2019 9 19571
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senfeida
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Audited Supplier
JiangSu，China(CAS:1316214-52-4)ACY-1215
senfeida
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苏州高新区浒墅关经济技术开发区
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Amadis Chemical Company Limited
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Audited Supplier
ZheJiang，China(CAS:1316214-52-4)Ricolinostat
A852479in Stock/in Stock/in Stock99%/99%/99%1g/250mg/100mgInquiry/Inquiry/Inquiry30 August 2024Amadis Chemical Company Limited
Contact & Address Information
网周路99号
Contact: Fred
Phone: 18658880036
Web: https://www.amadischem.com/
Business Type:Manufacturers
3 Main Products
Gold Member
Audited Supplier
ZheJiang，ChinaContact Now
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| Brand:Acmec | Supplier:上海吉至生化科技有限公司 | ||||||
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| No. | Purity | Stock | Specification | Price | update time | operate | |
| R37370-25mg | 现货 | 25mg | ¥1199.0 | 08 Sep. 2021 | |||
| R37370-5mg | 现货 | 5mg | ¥399.0 | 08 Sep. 2021 | |||
| Brand:chemenu | Supplier:Chemenu | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| CM166756-100mg | 98% | 1-2 Weeks | 100mg | $252 | 05 Aug. 2021 | ||
| CM166756-1g | 98% | in stock | 1g | $300 | 02 Mar. 2022 | ||
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