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- 1239262-52-2
- Tubastatin A
- Tubastatin A Trifluoroacetate
- Tubastatin A Trifluoroacetic Acid Salt
- N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide 2,2,2-trifluoroacetate
- Tubastain A
- TUBASTANTIN A
- Tubastatin A (trifluoroacetate salt)
- Tubastatin A Trifluo
- [4-({2-methyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-5-yl}methyl)phenyl]formamido 2,2,2-trifluoroacetate
- N-hydroxy-4-({2-methyl-1H,3H,4H-pyrido[4,3-b]indol-5-yl}methyl)benzamide hydrochloride
- N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide
- TRIETHYLENETHIOPHOSPHORAMIDE,WHITE SOLID
- TUBASTATIN A HYDROCHLORIDE
- TUBASTATIN A_HCL
- TUBASTSTINA HCL
- N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-trifluoroacetate
- N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
- 2,2,2-trifluoroacetic acid
- N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate
- N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide hydrochloried
- N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide TFA salt
- Tubastatin A TFA
- J-004997
- Tubastatin TFA salt
- Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, 2,2,2-trifluoroacetate (1:1)
- 1239262-52-2
- trifluoroacetic acid
- tubastatin A
- HY-13271B
- A890636
- Tubastatin A (TFA)
- D82920
- AKOS024465038
- CS-0007786
- AS-79588
- GLXC-10161
- S0709
- MFCD24873137
- N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide2,2,2-trifluoroacetate
- DB-352571
- MDL：MFCD20488052
- InChIKey：AVAOVICSJJIYRZ-UHFFFAOYSA-N
- Inchi：InChI=1S/C20H21N3O2.C2HF3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;3-2(4,5)1(6)7/h2-9,25H,10-13H2,1H3,(H,21,24);(H,6,7)
- SMILES：O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1.O=C(O)C(F)(F)F
Computed Properties
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Exact Mass: 449.4g/mol
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Surface Charge: 0
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Hydrogen Bond Donor Count: 3
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Hydrogen Bond Acceptor Count: 8
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Rotatable Bond Count: 3
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Monoisotopic Mass: 449.156241g/mol
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Monoisotopic Mass: 449.156241g/mol
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Topological Polar Surface Area: 94.8Ų
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Heavy Atom Count: 32
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Complexity: 561
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Isotope Atom Count: 0
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Defined Atom Stereocenter Count: 0
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Undefined Atom Stereocenter Count : 0
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Defined Bond Stereocenter Count: 0
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Undefined Bond Stereocenter Count: 0
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Covalently-Bonded Unit Count: 2
Experimental Properties
- LogP: 3.75860
- PSA: 94.80000
- Density: 1.3±0.1 g/cm3
- Safety Instruction：H303+H313+H333
- Hazard Statement：H303+H313+H333
- Warning Statement：P264+P280+P305+P351+P338+P337+P313
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
- Signal Word：warning
- 1. Actin filaments play a primary role for structural integrity and viscoelastic response in cells Alperen N. Ketene,Paul C. Roberts,Amanda A. Shea,Eva M. Schmelz,Masoud Agah Integr. Biol. 2012 4 540
- 2. Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A Rob De Vreese,Tom Verhaeghe,Tom Desmet,Matthias D'hooghe Chem. Commun. 2013 49 3775
- 3. Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors Rob De Vreese,Yves Depetter,Tom Verhaeghe,Tom Desmet,Veronick Benoy,Wanda Haeck,Ludo Van Den Bosch,Matthias D′hooghe Org. Biomol. Chem. 2016 14 2537
- 4. A highly HDAC6-selective inhibitor acts as a fluorescent probe Yi-Hsun Ho,Kuang-Jui Wang,Pei-Yun Hung,Yi-Sheng Cheng,Jia-Rong Liu,Sheang-Tze Fung,Pi-Hui Liang,Ji-Wang Chern,Chao-Wu Yu Org. Biomol. Chem. 2018 16 7820
- 5. Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors Rob De Vreese,Nicholas Van Steen,Tom Verhaeghe,Tom Desmet,Nadia Bougarne,Karolien De Bosscher,Veronick Benoy,Wanda Haeck,Ludo Van Den Bosch,Matthias D'hooghe Chem. Commun. 2015 51 9868
- 6. Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors D. Diedrich,A. Hamacher,C. G. W. Gertzen,L. A. Alves Avelar,G. J. Reiss,T. Kurz,H. Gohlke,M. U. Kassack,F. K. Hansen Chem. Commun. 2016 52 3219
- 7. Shifting the paradigm in treating multi-factorial diseases: polypharmacological co-inhibitors of HDAC6 Alexandria M. Chan,Steven Fletcher RSC Med. Chem. 2021 12 178
- 8. Borinostats: solid-phase synthesis of carborane-capped histone deacetylase inhibitors with a tailor-made selectivity profile Christoph Selg,Andrea Sch?ler,Julian Schliehe-Diecks,Maria Hanl,Laura Sinatra,Arndt Borkhardt,Menyhárt B. Sárosi,Sanil Bhatia,Evamarie Hey-Hawkins,Finn K. Hansen Chem. Sci. 2021 12 11873
- 9. Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition Yves Depetter,Silke Geurs,Flore Vanden Bussche,Rob De Vreese,Jorick Franceus,Tom Desmet,Olivier De Wever,Matthias D'hooghe Med. Chem. Commun. 2018 9 1011
- 10. Next-generation of selective histone deacetylase inhibitors Feifei Yang,Na Zhao,Di Ge,Yihua Chen RSC Adv. 2019 9 19571
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Mebhydrolin napadisilate CAS No.: 6153-33-9 -
Tryptoline CAS No.: 16502-01-5 -
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Amadis Chemical Company Limited
Gold Member
Audited Supplier
ZheJiang，China(CAS:1239262-52-2)Tubastatin A Trifluoroacetic Acid Salt
A890636in Stock/in Stock/in Stock99%/99%/99%1g/250mg/100mgInquiry/Inquiry/Inquiry30 August 2024Amadis Chemical Company Limited
Contact & Address Information
网周路99号
Contact: Fred
Phone: 18658880036
Web: https://www.amadischem.com/
Business Type:Manufacturers
3 Main Products
Gold Member
Audited Supplier
ZheJiang，ChinaContact Now
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0.0 1 week 1-2 Weeks In China Stock in stock 上海：6/安徽：3/武汉：5/成都：> 10/天津:/深圳: 上海：8/安徽：1/武汉：2/成都：> 10/天津:/深圳: 现货 中国:-/USA:-+ multiple choice
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1PlusChem A2B Chem LLC Aaron abcr Ambeed Chemenu eNovation Chemicals LLC Selleck中国 TRC 上海阿拉丁生化科技股份有限公司 上海皓鸿生物医药科技有限公司 上海吉至生化科技有限公司 上海贤鼎生物科技有限公司 圣克鲁斯生物技术 武汉安捷凯生物医药科技有限公司+ multiple choice
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| Brand:enovation | Supplier:eNovation Chemicals LLC | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| Y0973917-1g | 98% | 1g | $2500 | 04 Jun. 2024 | |||
| Brand:selleck | Supplier:Selleck中国 | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| S0709-25mg | 98.64% | 现货 | 25mg | ¥2970.75 | 15 Sep. 2023 | ||
| S0709-5mg | 98.64% | 现货 | 5mg | ¥970.91 | 15 Sep. 2023 | ||
| Brand:chemenu | Supplier:Chemenu | ||||||
|---|---|---|---|---|---|---|---|
| No. | Purity | Stock | Specification | Price | update time | operate | |
| CM148647-1g | 95% | 1-2 Weeks | 1g | $2434 | 13 Jun. 2022 | ||
| CM148647-250mg | 95% | 1-2 Weeks | 250mg | $1060 | 13 Jun. 2022 | ||
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