克里唑蒂尼 | 877399-52-5
中文名称:
克里唑蒂尼
英文名称:
Crizotinib
CAS No.:
877399-52-5
分子式:
C2 1 H2 2 Cl2 FN5 O
分子量:
450.336685657501
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:克里唑蒂尼结构式
简介
克里唑蒂尼是一种抗癌药物,由美国辉瑞公司研发。
名称和标识符
MDL
MFCD12407409
InChIKey
KTEIFNKAUNYNJU-GFCCVEGCSA-N
Inchi
1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
SMILES
O(C1C(N)=NC=C(C2C=NN(C3CCNCC3)C=2)C=1)[C@@H](C1C(Cl)=CC=C(F)C=1Cl)C
别名信息
- 中文别名 -
克里唑蒂尼
3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺
克唑替尼
3-[(R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(哌啶-4-基)-1H-吡唑-4-基]吡啶-2-胺
科研实验克唑替尼
克里唑啼尼
克里唑替尼
克里唑替尼杂质
克唑替尼标准品
克唑替尼粉末
克唑替尼固体状
克唑替尼中间体
临床实验克唑替尼
医药级克唑替尼
Crizotinib 克唑替尼
克里唑蒂尼,PF-2341066
克卓替尼
- 英文别名 -
2-Pyridinamine,3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
Crizotinib Xalkori
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine
Crizotinib
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-...
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
2-Pyridinamine,3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-...
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
Crizotinib(PF-2341066,Xalkori®)
Crozotinib
PF2341066
PF-2341066
PF-2341066 (Crizotinib)
Posaconazole inter-2 3H-1,2,4-Triazol-3-one,2-[(1S,2S)-1-ethyl-2-(phenylmethoxy)propyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-2-piperazinyl]phenyl]-
(R)-Crizotinib
Xalkori
(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
PF 2341066
PF-02341066
PF02341066
PF 02341066
53AH36668S
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-am
3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine (ACI)
(R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine
3-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
[3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine
物化性质
实验特性
LogP
5.94770
PSA
77.99000
折射率
1.673
沸点
599.177°C at 760 mmHg
熔点
197-203°C
蒸气压
No data available
闪点
316.171°C
溶解度
生物体外In Vitro:DMSO溶解度55 mg/mL(122.13 mM;Need ultrasonic)
颜色与性状
No data available
密度
1.475
计算特性
精确分子量
449.11900
氢键供体数量
2
氢键受体数量
6
可旋转化学键数量
5
重原子数量
30
复杂度
558
拓扑分子极性表面积
78
海关数据
海关编码
2933990090
海关数据
中国海关编码:
2933990090
概述:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素:
品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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克里唑蒂尼推荐生产厂家
克唑替尼
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克里唑蒂尼
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克唑替尼
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电话:021-58000709
联系人:许经理
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