8063-07-8
（卡那霉素碱,kanamycin）
卡那霉素碱
kanamycin
8063-07-8
C18H36N4O11
484.49864
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：卡那霉素碱结构式 名称和标识符
| MDL | MFCD00070289 |
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| InChIKey | SBUJHOSQTJFQJX-NOAMYHISSA-N |
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| Inchi | InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1 |
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| SMILES | OC[C@H]1O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@H](O)[C@@H](N)[C@@H]1O |
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别名信息
- 英文别名 -
- kanamycin
- KANAMYCIN A
- KANAMYCIN BASE
- 4))-2-deoxy-y-alpha-d-glucopyranosyl-(
- 4,6-diamino-2-hydroxy-1,3-cyclohexane3,6’diamino-3,6'-dideoxydi-alpha-d-gluc
- 4,6-diamino-2-hydroxy-1,3-cyclohexane3,6’diamino-3,6’-dideoxydi-alpha-d-glucos
- d-deoxydi
- Kanamycin Monosulfate
- Kanabristol
- KANAMYCIN A [WHO-IP]
- D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1,4))-2-deoxy-
- (1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
- Kanamycins
- KANAMYCIN A [HSDB]
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
- Kanamycin sulfate, Antibiotic for Culture Media Use Only
- Kanamycin A Deuterated
- AS-14003
- 8063-07-8
- UNII-RUC37XUP2P
- A07AA08
- EINECS 200-411-7
- DTXSID2041171
- 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside
- BSPBio_000607
- D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-2-DEOXY-
- EN300-19735925
- S01AA24
- Kanamycin Complex
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-2-hydroxycyclohexyloxy)tetrahydro-2H-pyran-3,4,5-triol
- NCGC00179506-01
- BPBio1_000669
- KM (the Antibiotic)
- Kantrex (1:1 sulfate)
- 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside
- IDI1_000024
- SBUJHOSQTJFQJX-NOAMYHISSA-N
- Kanamycinum
- KAN
- Kanamicina
- KanamycinA
- Prestwick3_000394
- SMP2_000007
- DivK1c_000024
- 59-01-8
- J01GB04
- Kanamycinum [INN-Latin]
- (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
- DTXCID503184
- CHEBI:6104
- D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-
- Kanamycin A monosulfate
- AKOS025293505
- Klebcil (1:1 sulfate)
- Kanamycine
- Kanamycin,(S)
- HY-16566
- Kanamycinum (Latin)
- UNII-EQK9Q303C5
- KANAMYCIN A [MI]
- Q27094615
- Glucopyranoside, 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-, D-
- Kanamycin [INN:BAN]
- RUC37XUP2P
- NS00098990
- EINECS 232-512-7
- Kanamycin Base
- D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-
- BRN 0061647
- CHEBI:17630
- D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)]-2-deoxy-
- SCHEMBL2735
- O-3-Amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy-D-streptamine
- Liposomal Kanamycin
- 2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
- K-0250
- HSDB 3107
- ANTIBIOTIC COMPLEX FROM STREPTOMYCES KANAMYCETICUS CONTAINING KANAMYCIN A (MAJOR), KANAMYCIN B AND KANAMYCIN C
- CS-0006792
- Kanamycine [INN-French]
- GTPL12132
- AB00513827
- Kanamicina [Italian]
- KBio1_000024
- BRD-K08327065-065-01-9
- BDBM50031282
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol
- DB01172
- NINDS_000024
- (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol
- O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine
- EQK9Q303C5
- D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.4))-2-deoxy-
- NCGC00179506-05
- CHEMBL1384
- C01822
- DTXSID3023184
- BRD-K08327065-065-04-3
- BRD-K08327065-065-04-3
- 1174286-24-8
- 1174286-24-8
物化性质
实验特性
| LogP | -6.3 |
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| 熔点 | 275°C (dec.) |
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| 稳定性 | Stability Incompatible with strong oxidizing agents. |
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| 密度 | 1.63 |
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计算特性
| 精确分子量 | 484.23805798g/mol |
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| 氢键供体数量 | 11 |
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| 氢键受体数量 | 15 |
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| 可旋转化学键数量 | 6 |
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| 同位素质量 | 484.23805798g/mol |
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| 重原子数量 | 33 |
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| 复杂度 | 638 |
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| 同位素原子数量 | 0 |
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| 确定原子立构中心数量 | 15 |
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| 不确定原子立构中心数量 | 0 |
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| 确定化学键立构中心数量 | 0 |
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| 不确定化学键立构中心数量 | 0 |
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| 共价键单元数量 | 1 |
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| 疏水参数计算参考值（XlogP） | -6.9 |
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| 拓扑分子极性表面积 | 283Ų |
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相关文献
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Shanta Dhar,Munirathinam Nethaji,Akhil R. Chakravarty Dalton Trans. 2004 4180 - 2. Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance
Torsten John,Zhi Xiang Voo,Clemens Kubeil,Bernd Abel,Bim Graham,Leone Spiccia,Lisandra L. Martin Med. Chem. Commun. 2017 8 1112 - 3. Schiff base formation and recognition of amino sugars, aminoglycosides and biological polyamines by 2-formyl phenylboronic acid in aqueous solution
Nini J. Gutiérrez-Moreno,Felipe Medrano,Anatoly K. Yatsimirsky Org. Biomol. Chem. 2012 10 6960 - 4. Influence of charge and structure on the coordination chemistry of copper aminoglycosides
Anjali Patwardhan,J. A. Cowan Dalton Trans. 2011 40 1795 - 5. RE-SELEX: restriction enzyme-based evolution of structure-switching aptamer biosensors
Aimee A. Sanford,Alexandra E. Rangel,Trevor A. Feagin,Robert G. Lowery,Hector S. Argueta-Gonzalez,Jennifer M. Heemstra Chem. Sci. 2021 12 11692 - 6. A library screening approach identifies naturally occurring RNA sequences for a G-quadruplex binding ligand
Gayan Mirihana Arachchilage,Mark J. Morris,Soumitra Basu Chem. Commun. 2014 50 1250 - 7. Copper(ii) binding by kanamycin A and hydrogen peroxide activation by resulting complexes
Wojciech Szczepanik,Piotr Kaczmarek,Jaros?aw Sobczak,Wojciech Bal,Kazimierz Gatner,Ma?gorzata Je?owska-Bojczuk New J. Chem. 2002 26 1507 - 8. Selective modification of the 3′′-amino group of kanamycin prevents significant loss of activity in resistant bacterial strains
Andrés G. Santana,Sandra G. Zárate,Juan Luis Asensio,Julia Revuelta,Agatha Bastida Org. Biomol. Chem. 2016 14 516 - 9. Design of an aptamer – based fluorescence displacement biosensor for selective and sensitive detection of kanamycin in aqueous samples
Long Ma,Nana Sun,Chunhao Tu,Qian Zhang,Aipo Diao RSC Adv. 2017 7 38512 - 10. Complete dissociation and reassembly behavior as studied by using poly(ethylene glycol)-block-poly(glutamate sodium) and kanamycin A
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