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乙酰唑胺 | 59-66-5

乙酰唑胺
Acetazolamide
59-66-5
C4H6N4O3S2
222.2454
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:乙酰唑胺结构式
329770545
乙酰唑胺价格
简介
乙酰唑胺(Acetazolamide),中华药典名为乙酰偶氮胺,商品名为丹木斯(Diamox),学名为N-(5-氨磺酰基-1,3,4-噻二唑-2-基)乙酰胺。乙酰唑胺为利尿药。碳酸酐酶抑制剂,服后抑制肾小管上皮细胞中的碳酸酐酶,使H2CO3的形成减少,H+的产生随之下降。因此,H+与Na+的交换大为减慢,结果HCO3-、Na+、K+排出增加,尿量增多。该品尚能抑制房水分泌过程,使眼压下降。用于治疗青光眼,轻度心脏性水肿等。
名称和标识符
MDL MFCD00003105
InChIKey BZKPWHYZMXOIDC-UHFFFAOYSA-N
Inchi 1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
SMILES S(C1=NN=C(N([H])C(C([H])([H])[H])=O)S1)(N([H])[H])(=O)=O
BRN 212994
别名信息
- 中文别名 -
  • 乙酰唑胺
  • N-[5-(氨磺酰基)-1,3,4-噻二唑-2-基]乙酰胺
  • 17-氨基-3,6,9,12,15-五氧杂十七烷醇
  • 醋唑磺胺
  • 醋唑磺胺 EP标准品
  • 醋唑磺胺系统适用性 EP标准品
  • 三磷酸腺苷二钠(ATP)
  • 乙酰唑胺 USP标准品
  • 乙酰唑胺 标准品
  • 乙酰唑胺-13C2-D3
  • 乙酰唑胺杂质
  • 2-乙酰氨基-1,3,4-噻二唑-5-磺酰胺
  • ACET偶氮酰胺
  • 阿昔洛韦杂质A
  • 代马克司
  • 代冒克斯
  • 丹木斯
- 英文别名 -
  • acetazolamide
  • 2-acetamido-5-sulfamoyl-1,3,4-thiadiazole
  • 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
  • 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
  • N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
  • 5-acetamido-1,3,4-thiadiazole-2-sulphonamide
  • Cidamex
  • DIACARB
  • Diakarb
  • Diamox
  • Didoc
  • Diluran
  • Donmox
  • Edemox
  • Glupax
  • N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
  • N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide
  • Acetazolamid
  • Glaupax
  • Defiltran
  • Nephramide
  • Acetamox
  • Phonurit
  • Nephramid
  • Dehydratin
  • Natrionex
  • Duiramid
  • Diuramid
  • Eumicton
  • Diutazol
  • Vetamox
  • Fonurit
  • SK-acetazolamide
  • Diuriwas
  • Acetozalamide
  • Acetazolamidum
  • Acetazolamida
  • Acetazoleamide
  • Diureticum-holzinger
  • Acetamidothiadiazolesulfonamide
  • Acetazolamine
  • Atenezol
  • Diamox Sequels
  • 4-D
  • Glaumox
  • Acetazolamide (AAZ)
  • 5-acetylamino-1,3,4-thiadiazole-2-sulfonamide
  • MLS001148438
  • Q-200580
  • HMS3712A07
  • A832415
  • KBioGR_000558
  • ACETAZOLAMIDE [WHO-DD]
  • Carbonic Anhydrase Inhibitor No. 6063
  • Acetazolamide Dioptic Brand
  • D88526
  • ACETAZOLAMIDE [EP MONOGRAPH]
  • Acetazolamide [USP:INN:BAN:JAN]
  • ACETAZOLAMIDE [VANDF]
  • CARBONIC ANHYDRASE INHIBITOR NO 6063
  • NCGC00015074-08
  • 1ydb
  • Acetazolamidum [INN-Latin]
  • CS-3568
  • SPBio_000004
  • Acetazolamide, >=99%, powder
  • NSC-145177
  • Grin Brand of Acetazolamide
  • C4H6N4O3S2
  • NCGC00015074-10
  • HY-B0782
  • NC00491
  • ACETAZOLAMIDE [JAN]
  • 3hs4
  • Medphano Brand of Acetazolamide
  • Diuramide
  • NSC145177
  • LP00039
  • BCP29616
  • Acetazolamide for system suitability, European Pharmacopoeia (EP) Reference Standard
  • CAS-59-66-5
  • Pharmakon1600-01500102
  • Acetazolamide Medphano Brand
  • NCGC00015074-04
  • SPECTRUM1500102
  • Jumer Brand of Acetazolamide
  • Acetazolamide, AAZ
  • SMR000058394
  • ACETAZOLAMIDE [HSDB]
  • SR-01000000065
  • Acetazolam
  • 3czv
  • Lopac-A-6011
  • NCGC00015074-15
  • D0E1SW
  • EU-0100039
  • DivK1c_000017
  • C4-H6-N4-O3-S2
  • Acetazolamide (JP15/USP/INN)
  • Tox21_110078
  • HMS500A19
  • N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
  • Acetazolamide Wassermann Brand
  • NCGC00015074-03
  • ACETAZOLAMIDE (MART.)
  • Tox21_110078_1
  • Ak Zol
  • Diamox (TN)
  • Acetazolamide [BAN:INN:JAN]
  • ACETAZIDE
  • ICN Brand of Acetazolamide
  • Acetazolamide Llorens Brand
  • Acetazolamide [INN:BAN:JAN]
  • SDCCGSBI-0050028.P005
  • 3ucj
  • Chiesi Brand of Acetazolamide
  • CS-O-07116
  • Prestwick0_000003
  • HumaZolamide
  • Atenezo
  • O3FX965V0I
  • Acetazolamide, European Pharmacopoeia (EP) Reference Standard
  • 2h4n
  • 2xtk
  • BDBM10880
  • Acetazolamide Jumer Brand
  • 3dc3
  • SPBio_001926
  • ACETAZOLAMIDE [INN]
  • 4g0c
  • ACETAZOLAMIDE [USP-RS]
  • Spectrum4_000139
  • BRD-K43457670-001-22-9
  • N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-acetamide
  • HMS1568A07
  • Llorens Brand of Acetazolamide
  • 5-Acetamide-1,4-thiadiazole-2-sulfonamide
  • Storzolamide
  • Acetazolamide, analytical standard
  • s4506
  • ACETAZOLAMIDUM [WHO-IP LATIN]
  • 2uy4
  • NSC-755854
  • 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide
  • BIDD:GT0643
  • IDI1_000017
  • ACETAZOLAMIDE [WHO-IP]
  • BSPBio_001788
  • HMS3744A21
  • Dioptic Brand of Acetazolamide
  • Dazamide
  • ATENAZOL
  • Huma Zolamide
  • NCGC00015074-05
  • 1azm
  • A 6011
  • HMS2232G23
  • 1ydd
  • NCGC00023455-05
  • Monosodium Salt Acetazolamide
  • EN300-119493
  • 2-ACETAMIDO-1,3,4-THIADIAZOLE-5-SULFONAMIDE
  • 4-Diamox
  • N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide
  • 1zsb
  • Prestwick_4
  • Acerazolamide, AAZ
  • ACETAZOLAMIDE [ORANGE BOOK]
  • CCG-38900
  • BPBio1_000007
  • 2-Acetamido-5-sulfonamido-1,4-thiadiazole
  • AB00051906
  • EINECS 200-440-5
  • Z277559108
  • 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
  • GTPL6792
  • 5-Acetamido-1,3,4-thiadiazol-2-sulfonamide
  • Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-
  • NCGC00023455-07
  • (1z)-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanimidic acid
  • Wyeth Brand of Acetazolamide Preparation
  • ApoAcetazolamide
  • NSC755854
  • NCGC00015074-06
  • AkZol
  • NCGC00015074-17
  • NCGC00260724-01
  • AS-13169
  • Acetazolamide Orion Brand
  • CCRIS 5811
  • 1,4-Thiadiazole-2-sulfonamide, 5-acetamido-
  • Apo-Acetazolamide
  • 1,3,4-THIADIAZOLE-2-SULFONAMIDE, 5-ACETAMIDO
  • HMS3259I13
  • Acetamida, N-[5-(aminosulfonil)-1,3,4-tiadiazol-2-il]-
  • Acetazolamide, Monosodium Salt
  • Acetazolamide (JP17/USP/INN)
  • Glauconox
  • SR-01000000065-4
  • N-[5-(Aminosulfonyl)-1,3,4-thiadiozol-2-yl]-Acetamide
  • 59-66-5
  • KBio2_002926
  • DTXSID7022544
  • AKOS000715163
  • NCGC00023455-06
  • HMS2095A07
  • Acetazolamide Sodium, (Sterile)
  • Acetazolamide Grin Brand
  • Acetazolamide ICN Brand
  • Prestwick3_000003
  • ACETAZOLAMIDE (USP-RS)
  • NCGC00023455-04
  • D00218
  • N-(5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl)acetamide
  • AB00051906_15
  • Tox21_500039
  • ACETAZOLAMIDE [USP MONOGRAPH]
  • Q-200579
  • Acetazolamide Chiesi Brand
  • KBio2_000358
  • AI3-52458
  • NCGC00015074-22
  • AZA2
  • BZKPWHYZMXOIDC-UHFFFAOYSA-
  • Orion Brand of Acetazolamide
  • C06805
  • ACETAZOLAMIDE (EP MONOGRAPH)
  • NCGC00015074-02
  • 1yda
  • HMS1920A05
  • KBio1_000017
  • N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanamide
  • Diacarb
  • Acetazolamide, United States Pharmacopeia (USP) Reference Standard
  • NSC 145177
  • Spectrum_000018
  • Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-
  • SBI-0050028.P004
  • NCGC00023455-03
  • Apo Acetazolamide
  • DiamoxSequels
  • ACETAZOLAMIDE [MART.]
  • Acetazolamida [INN-Spanish]
  • Ciba Vision Brand of Acetazolamide
  • UNII-O3FX965V0I
  • NCGC00015074-14
  • Opera_ID_288
  • Acetazolamide, Pharmaceutical Secondary Standard
  • Certified Reference Material
  • Spectrum2_000082
  • N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
  • BSPBio_000005
  • ACETAZOLAMIDE (USP MONOGRAPH)
  • BRD-K43457670-001-26-0
  • 1,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-
  • NCGC00015074-07
  • SCHEMBL11049053
  • SR-01000000065-6
  • Acetazolamide, 5
  • Prestwick1_000003
  • ACETAZOLAMIDE (EP IMPURITY)
  • 3ml5
  • Prestwick2_000003
  • 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide
  • Acetazolamide Apotex Brand
  • HMS3260G19
  • L 579486
  • S01EC01
  • 124442-28-0
  • Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-
  • Apotex Brand of Acetazolamide
  • DTXCID002544
  • Acetazolamide, AZM
  • NCGC00015074-11
  • WLN: T5NN DSJ CSZW EMV1
  • NCGC00015074-09
  • NCGC00015074-12
  • ACETAZOLAMIDE [MI]
  • ACETAZOLAMIDE [EP IMPURITY]
  • Tox21_201559
  • NCGC00259108-01
  • Carbonic anhydrase inhibitor 6063
  • MLS000028435
  • 1jd0
  • NCGC00256374-01
  • MFCD00003105
  • 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
  • AC-12779
  • Lopac0_000039
  • Acetazolamide, AZA
  • KBioSS_000358
  • SCHEMBL23219
  • Q413690
  • HMS3370P01
  • Acetazolamide Novopharm Brand
  • Spectrum5_000738
  • Huma-Zolamide
  • Wassermann Brand of Acetazolamide
  • Acetadiazol
  • Novopharm Brand of Acetazolamide
  • HMS2091G05
  • AMY3289
  • Ak-Zol
  • Spectrum3_000284
  • NINDS_000017
  • DB00819
  • Storz Brand of Acetazolamide Preparation
  • CHEMBL20
  • SR-01000000065-2
  • KBio3_001288
  • Tox21_302773
  • NCGC00015074-01
  • InChI=1/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
  • KBio2_005494
  • CHEBI:27690
  • HSDB 3002
  • Acetazolamide
  • Acetazolamide (Standard)
  • Acetazolamida (INN-Spanish)
  • CS-0694998
  • Acetazolamide (USP:INN:BAN:JAN)
  • Acetazolamidum (INN-Latin)
  • HY-B0782R
  • NS00008947
  • Acetazolamide Extended-Release
物化性质
实验特性
LogP 0.99800
PSA 151.66000
Merck 14,53
折射率 1.6270 (estimate)
水溶性 <0.1 g/100 mL at 22 ºC
沸点 °Cat760mmHg
熔点 256-261 ºC
闪点 °C
溶解度 Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol.
颜色与性状 白色针状结晶或结晶性粉末
溶解性 略溶于沸水,微溶于水,乙醇,几乎不溶于氯仿或乙醚,易溶于氨溶液。
酸度系数(pKa) 7.2(at 25℃)
最大波长(λmax) 265nm(H2O)(lit.)
密度 1.610 (estimate)
计算特性
精确分子量 221.98800
氢键供体数量 2
氢键受体数量 7
可旋转化学键数量 2
同位素质量 221.988
重原子数量 13
复杂度 297
同位素原子数量 0
确定原子立构中心数量 0
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) -0.3
互变异构体数量 5
表面电荷 0
拓扑分子极性表面积 152
国际标准相关数据
EINECS 200-440-5
海关数据
海关编码 2935009090
海关数据

中国海关编码:

2935009090

概述:

2935009090 其他磺(酰)胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%

申报要素:

品名, 成分含量, 用途

Summary:

2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

生产方法和用途
方法
1.氯化、氧化2-乙酰氨基-5-巯基-1,3,4-噻二唑加入冰醋酸及水混合液中,冷却至-2℃通氯,终温不超过5℃。当物料温度显著下降,液面有大量泡沫出现,液氯耗用至规定量时停止通氯,过滤,滤饼用冰水洗涤至pH为4,得氯氧化物(2-乙酰氯基-5-磺酰氯-1,3,4-噻二唑)。2.胺化将氨水与碎冰混合,降温至5℃以下。加入氯氧化物,加毕,保温反应半小时。用盐酸调节pH至5-6,过滤,滤饼洗涤至pH为7,干燥,得乙酰唑胺粗品。将粗品、水、活性炭及偏重亚硫酸钠加热至95℃,脱色1-1.5h,趁热过滤,滤液冷却结晶,过滤,洗涤,干燥,得乙酰唑胺。
用途
该品为利尿药。为碳酸酐酶抑制剂,服后抑制肾小管上皮细胞中的碳酸酐酶,使H2CO3的形成减少,H+的产生随之下降。因此,H+与Na+的交换大为减慢,结果HCO3-,Na+,K+排出增加,尿量增多。该品尚能抑制房水分泌过程,使眼压下降。用于治疗青光眼,轻度心脏性水肿等。
专业数据库参考
PubChemId 329770545
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