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吲哚美辛 | 53-86-1

吲哚美辛
Indomethacin
53-86-1
C19H16ClNO4
357.7876
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:吲哚美辛结构式
3715
吲哚美辛价格
简介
Indomethacin (Indometacin) 是一种有效的口服活性 COX1/2 抑制剂,COX-1 和 COX-2 的IC50 值分别为 18 nM 和 26 nM。Indomethacin 具有抗癌和抗感染活性。Indomethacin 可用于癌症、炎症和病毒感染的研究。
名称和标识符
MDL MFCD00057095
InChIKey CGIGDMFJXJATDK-UHFFFAOYSA-N
Inchi 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
SMILES ClC1C([H])=C([H])C(=C([H])C=1[H])C(N1C(C([H])([H])[H])=C(C([H])([H])C(=O)O[H])C2C([H])=C(C([H])=C([H])C1=2)OC([H])([H])[H])=O
BRN 497341
别名信息
- 中文别名 -
  • 吲哚美辛
  • 美辛
  • 茚甲新
  • 消炎痛
  • 抗炎吲哚酸
  • 吲哚美辛D4
  • 消炎痛,吲哚美辛
  • 吲哚美辛(消炎痛)
  • 吲哚美辛钾
  • 1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-乙酸
  • 1-对氯苯甲酰-5-甲氧基-2-甲基吲哚乙酸
  • 吲哚美辛 EP标准品
  • 吲哚美辛 USP标准品
  • 吲哚美辛 标准品
  • 吲哚美辛 消炎痛
  • 吲哚美辛(消炎痛) BP2002
  • 吲哚美辛(药品)
  • 吲哚美辛-D4
  • 吲哚美辛标准品(JP)
  • 吲哚美辛钠
  • 1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚乙酸
  • 吲哚美辛(对照品)
- 英文别名 -
  • Indomethacin
  • indomethacin methanol solution
  • indomethacin crystalline
  • indomethacin usp
  • indometacin
  • 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid
  • INDOMETACIN POTASSIUM
  • 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic Acid
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
  • 吲哚美辛
  • Indocin
  • Indometacine
  • Indomethacine
  • Indocid
  • Metindol
  • Indomethazine
  • Imbrilon
  • Amuno
  • Tannex
  • Indomethacinum
  • Mikametan
  • Methazine
  • Indoptol
  • Confortid
  • Artracin
  • Inflazon
  • Indomecol
  • Metartril
  • Infrocin
  • Indoptic
  • Artrivia
  • Sadoreum
  • Reumacide
  • Idomethine
  • Artrinovo
  • Lausit
  • Indacin
  • Dolovin
  • Metacen
  • Indomee
  • Inacid
  • Indomed
  • Mobilan
  • Indo-tablinen
  • Indo-rectolmin
  • Inteban sp
  • Indometicina
  • Indometacyna
  • Mezolin
  • Indo-Lemmon
  • Indocin Sr
  • Indometacinum
  • Indometacina
  • Indomethine
  • Elmetacin
  • Dolcidium
  • In
  • Indometacin
  • 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
  • 1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico
  • DivK1c_000271
  • BSPBio_000144
  • SBI-0050670.P004
  • SR-01000000014-4
  • HMS1362I11
  • BRD-K57222227-001-18-6
  • 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-H-indole-3-acetic acid
  • Indomethacin,(S)
  • HMS3268A14
  • CHEBI:49662
  • BIDD:GT0132
  • O-Desmethyl-des-4-chlorobenzoylacemetacin
  • Tox21_113109
  • 1z9h
  • SMR000058195
  • SR-01000000014-16
  • Indometacina [INN-Spanish]
  • NCGC00024135-12
  • Indomod
  • 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl}acetic acid
  • IMN
  • INDOMETHACIN [USAN]
  • Chrono-indocid
  • HMS2095H06
  • INDOMETHACIN [ORANGE BOOK]
  • Indomethacin ER
  • NCI-C56144
  • M02AA23
  • Lopac-I-7378
  • BRN 0497341
  • NCGC00024135-15
  • Aconip (TN)
  • NCGC00015562-19
  • (1-((4-chlorophenyl)carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid
  • NCGC00015562-16
  • NCGC00015562-18
  • AB00052022_24
  • Indonol
  • NCGC00254075-01
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-met hyl-1H-indole
  • HMS1990I11
  • AB00052022_23
  • SDCCGSBI-0050670.P005
  • SCHEMBL9300
  • I0655
  • INDREN
  • [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
  • Indomethacin, Pharmaceutical Secondary Standard
  • Certified Reference Material
  • Flexin continus
  • INDOMETACIN [JAN]
  • BPBio1_000160
  • Prestwick2_000272
  • NCGC00024135-10
  • INDOMETACIN [WHO-DD]
  • Prestwick_597
  • INDOMETACINUM [WHO-IP LATIN]
  • NCGC00024135-06
  • NCGC00024135-14
  • Lopac0_000692
  • KBio2_003967
  • FLAM
  • CCG-40186
  • GTPL1909
  • Inteban
  • BSPBio_001149
  • HMS3678N11
  • Durametacin
  • NCI60_041708
  • INDOMETACIN [EP MONOGRAPH]
  • Tox21_113109_1
  • BIM-0050670.0001
  • 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
  • Hicin
  • INDOMETHACIN (USP MONOGRAPH)
  • NCGC00015562-13
  • Q-201239
  • Indometacine [INN-French]
  • (1-p-Chlorobenzoyl-5-methoxy-2-methylindol-3-yl)acetic acid
  • CHEMBL6
  • Miametan
  • HMS3655O04
  • Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl- (8CI)
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
  • NCGC00015562-02
  • NCGC00015562-07
  • 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
  • AB00052022
  • SPECTRUM1500350
  • AT13679
  • 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
  • Spectrum5_000868
  • Indomethacin & MAP-30
  • UNII-XXE1CET956
  • BRD-K57222227-001-27-7
  • Indmethacine
  • NSC757061
  • KBioGR_000395
  • INDOMETHACIN (USP-RS)
  • FT-0603227
  • Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
  • 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1h-indol-3-yl}acetic acid
  • INDOMETACIN (EP MONOGRAPH)
  • 4kyk
  • HMS1568H06
  • INDOMETACIN [MART.]
  • MLS001074194
  • Indomethacin [USAN:USP]
  • INDOMETHACIN [HSDB]
  • NCGC00015562-21
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- (9CI)
  • AB00052022-20
  • Spectrum3_000468
  • IndomethacinER
  • HMS3430L03
  • NCGC00024135-05
  • MFCD00057095
  • NCGC00015562-06
  • Indometacina (INN-Spanish)
  • Indolar SR
  • KS-5255
  • EU-0100692
  • MLS006011845
  • Spectrum_000919
  • .alpha.-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid
  • 1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure [German]
  • NCGC00015562-08
  • DB00328
  • INDOMETACIN [WHO-IP]
  • Indomethacin, European Pharmacopoeia (EP) Reference Standard
  • Indomethacin (Indocid, Indocin)
  • Indometacinum (INN-Latin)
  • KBioGR_000489
  • NCGC00024135-09
  • M01AB01
  • HMS3747K21
  • 2-{1-((4-chlorophenyl)carbonyl)-5-methoxy-2-methylindol-3-yl}acetic acid
  • indomethacin
  • NCGC00024135-07
  • UPCMLD-DP023
  • Bio2_000405
  • 1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • NS00000217
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindol-3-acetic acid
  • NCGC00015562-10
  • Indomethacin (USP)
  • 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2 methylindol-3-yl}acetic acid
  • 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indol acetic acid
  • N-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
  • Prestwick1_000272
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
  • KBio3_000897
  • NCGC00015562-15
  • Bonidon Gel
  • Osmosin
  • NCGC00015562-40
  • Tox21_201791
  • INDOMETHACIN [MI]
  • 1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetic acid
  • DTXSID9020740
  • Innamit
  • KBio2_003057
  • HMS2231J10
  • BRD-K57222227-001-06-1
  • NCGC00015562-14
  • Bio2_000885
  • BCP18951
  • 53-86-1
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-Indole-3-acetic acid
  • KBioSS_000489
  • KBio2_001399
  • Indomethacin, >=99.0% (TLC)
  • HMS3374F07
  • NCGC00015562-20
  • AKOS000592893
  • DTXCID50740
  • SPBio_000979
  • Aconip
  • N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid
  • INDOMETHACIN [USP MONOGRAPH]
  • Q409231
  • Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy [Polish]
  • IDI1_002160
  • NSC77541
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid & MAP-30
  • Indocin (TN)
  • Indo-Spray
  • MolMap_000032
  • NCGC00259340-01
  • 1-(p-Chlorobenzoyl)-2-methoxy-3-methyl-1H-indole-3-acetic Acid
  • NCGC00015562-24
  • HY-14397
  • Tocris-1708
  • InChI=1/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
  • 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
  • 5-22-05-00239 (Beilstein Handbook Reference)
  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
  • Indomethacin (USAN:USP)
  • NCGC00015562-11
  • Indomethacin Extended-release
  • CAS-53-86-1
  • Bonidin
  • Indomethacin-d4(chlorobenzoyl-d4)
  • Tivorbex
  • Pharmakon1600-01500350
  • HMS1792I11
  • NCGC00015562-25
  • USAN
  • BSPBio_002176
  • HMS2089N19
  • Tox21_300266
  • Spectrum2_000970
  • BDBM17638
  • D00141
  • Vonum
  • Indometacin (JP17/INN)
  • Indomethancin
  • s1723
  • AC-532
  • NCGC00015562-04
  • Spectrum4_000018
  • CHRONO-INDOCID 75
  • HMS3884E08
  • Chibro-amuno
  • Chrono-indicid
  • NSC 757061
  • HMS500N13
  • EN300-16807
  • N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
  • (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL)ACETIC ACID
  • UPCMLD-DP023:001
  • L000959
  • Catlep
  • INDOMETHACIN [USP-RS]
  • HMS1920F21
  • ACEMETACIN IMPURITY B [EP IMPURITY]
  • Indocid (pharmaceutical)
  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
  • ACEMETACIN IMPURITY B (EP IMPURITY)
  • S00108
  • Indomo
  • SR-01000000014
  • HMS3649K17
  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid
  • 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
  • INDOMETHACIN [VANDF]
  • CCRIS 3502
  • Indometicina [Spanish]
  • BP-30207
  • Indometacin 1.0 mg/ml in Acetonitrile
  • NCGC00024135-04
  • KBio2_000489
  • Kwas 1-(p-chlorobenzoilo)-2-metylo-5-metoksy-3-indolilooctowy
  • Indomethacin, Antibiotic for Culture Media Use Only
  • Rheumacin LA
  • Oprea1_686105
  • HSDB 3101
  • Prestwick0_000272
  • Indocin-SR
  • I 7378
  • [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid #
  • CGIGDMFJXJATDK-UHFFFAOYSA-
  • 1-p-chlorobenzoyl-2-methyl-5-methoxyindol-3-acetic acid
  • Arthrexin
  • EINECS 200-186-5
  • SR-01000000014-10
  • NSC-77541
  • NCGC00015562-05
  • Indometacin [INN]
  • NCGC00015562-09
  • HMS3414N13
  • KBio2_005625
  • Dolcidium PL
  • KBio2_006535
  • C01926
  • Indometacyna [Polish]
  • KBioSS_001399
  • 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2methylindol-3-yl}acetic acid
  • NCGC00024135-13
  • NCGC00024135-02
  • Opera_ID_56
  • Indoxen
  • MLS000069402
  • NSC-757061
  • INDOMETACIN (MART.)
  • NCGC00015562-12
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indole-acetic acid
  • Indomethacin, meets USP testing specifications
  • Indomethacin, >=99% (TLC)
  • HMS2091N09
  • 1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indoleacetic acid
  • LP00692
  • S01BC01
  • Indocollyre
  • Z56784896
  • Indomethacin, United States Pharmacopeia (USP) Reference Standard
  • Prestwick3_000272
  • SR-01000000014-2
  • KBio3_001396
  • Bonidon
  • Indometacinum (Latin)
  • NCGC00015562-01
  • 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
  • SR-01000000014-6
  • SW196768-5
  • NCGC00024135-11
  • NCGC00261377-01
  • NINDS_000271
  • Indochron E-R
  • HB4422
  • alpha-(1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolyl)acetic acid
  • Indomethacin - CAS 53-86-1
  • EC 200-186-5
  • AB00052022-21
  • Indo-phlogont
  • XXE1CET956
  • HMS3262K05
  • Indorektal
  • Indometacine (INN-French)
  • BI166166
  • 1-p-Cloro-benzoil-5-metoxi-2-metilindol-3-acido acetico [Spanish]
  • NCGC00024135-08
  • NCGC00015562-22
  • NCGC00015562-03
  • NCGC00015562-17
  • Indomethacine impurity mixture
  • KBio3_000898
  • SPBio_002363
  • Tox21_500692
  • IDI1_000271
  • HMS3403I11
  • KBio1_000271
  • Indometacinum [INN-Latin]
  • Indomet 140
  • HMS3712H06
  • C01EB03
  • Indameth
  • 1-(p-Chlorbenzoyl)-5-methoxy-2-methylindol-3-essigsaeure
  • Indometacin,99%
物化性质
实验特性
LogP 3.92730
PSA 68.53000
Merck 4968
折射率 1.6800 (estimate)
水溶性 Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
沸点 499.4°C at 760 mmHg
熔点 155-162?°C
蒸气压 8.61E-11mmHg at 25°C
闪点 255.8°C
溶解度 ethanol: 50 mg/mL, clear, yellow-green
颜色与性状 白色结晶粉末
稳定性 Stable. Incompatible with strong oxidizing agents.
溶解性 遇强碱分解。溶于乙醇、乙醚、丙酮和蓖麻油,几乎不溶于水。
Fluka 8-10
敏感性 Light Sensitive
酸度系数(pKa) 4.5(at 25℃)
密度 1.32g/cm3
计算特性
精确分子量 357.07700
氢键供体数量 1
氢键受体数量 4
可旋转化学键数量 4
同位素质量 357.076786
重原子数量 25
复杂度 506
同位素原子数量 0
确定原子立构中心数量 0
不确定原子立构中心数量 0
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) 4.3
互变异构体数量
表面电荷 0
拓扑分子极性表面积 68.5
国际标准相关数据
EINECS 200-186-5
海关数据
海关编码 2933290090
海关数据

中国海关编码:

2933990090

概述:

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素:

品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期

Summary:

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

生产方法和用途
方法
对氨基苯甲醚经重氮化、还原、酸化、水解、环合,得到消炎痛。
用途
为非激素类消炎镇痛药
该品抗炎,解热作用明显,主要用于对水杨酸类药物不易耐受或疗效不显著的风湿性并节炎、强直性光脊椎炎、骨关节炎等。
环加氧酶(COX)抑制剂,选择性地抑制COX-1;阻断前列腺索的生物合成。医药上抗炎,解热作用明显,主要用于对水杨酸类药物不易耐受或疗效不显著的风湿性并节炎、强直性光脊椎炎、骨关节炎等。
专业数据库参考
PubChemId 3715
参考资料
Reaxys RN 497341
Beilstein 497341
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