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阿托品 | 51-55-8

阿托品
Atropine
51-55-8
C17H23NO3
289.3694
如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:阿托品结构式
阿托品MSDS
24890401
阿托品价格
简介
Atropine (Tropine tropate) 是一种竞争性的毒碱乙酰胆碱受体 (mAChR) 拮抗剂,拮抗 Human mAChR M4 和 Chicken mAChR M4 的 IC50 值分别为 0.39 nM 和 0.71 nM。Atropine 抑制 ACh 诱导的人肺静脉松弛。Atropine 可用于抗近视和心动过缓研究。
名称和标识符
MDL MFCD00022622
InChIKey RKUNBYITZUJHSG-PJPHBNEVSA-N
Inchi 1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
SMILES O(C(C([H])(C([H])([H])O[H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)C1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C1([H])[H])N2C([H])([H])[H]
别名信息
- 中文别名 -
  • 阿托品
  • (8-甲基-8-氮杂双环[3.2.1]辛-3-基) 3-羟基-2-苯基-丙酸酯
  • 颠茄碱
  • 龙葵碱
  • 间甲氧基苯甲醛
  • 3-甲氧基苯甲醛
  • 茄苷
  • 茄碱
  • 茄灵
  • 顛茄鹼
  • 莨菪碱
  • 曼陀羅鹼
  • 托品鹼
  • (8-甲基-8-氮杂双环[3.2.1]辛-3-基) ENDO-(+/-)-ALPHA-(羟甲基)苯乙酸酯
  • 阿托品 EP标准品
  • 阿托品 标准品
  • 阿托品(含颠茄硷)杂质
  • 阿托品峰鉴别 EP标准品
  • 阿托品,颠茄碱
  • 颠茄碱 标准品
  • 颠茄碱【-02】
  • 颠茄碱【-02】(标准品)
  • (8-甲基-8-氮杂双环[3.2.1]辛-3-基) endo-(+/-)-α-(羟甲基)苯乙酸酯
  • (8-甲基-8-氮杂双环[3.2.1]辛-3-基) endo-(+/-)-alpha-(羟甲基)苯乙酸酯
- 英文别名 -
  • ATROPINE
  • DL-HYOSCYAMINE
  • (+/-)-HYOSCYAMINE
  • HYOSCYAMINE
  • TIMTEC-BB SBB005985
  • (+,-)-Tropyl tropate
  • 1-alpha-h,5-alpha-h-tropan-3-alpha-ol(+-)-tropate(ester)
  • 1alphah,5alphah-tropan-3alpha-ol(+-)-tropate(ester)
  • 2-Phenylhydracrylic acid 3-alpha-tropanyl ester
  • alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
  • alpha-(hydroxymethyl)benzeneaceticacid8-methyl-8-azabicyclo(3.2.1)oct-3-yl
  • Atropin
  • Atropina
  • Atropin-flexiolen
  • Atropinol
  • Atropine (DL-Hyoscyamine, Tropine tropate)
  • Atropine solution
  • -.)-tropate (ester)
  • Atropisol
  • DL-ATROPINE
  • DL-tropic acid tropane-3endo-yl ester
  • DL-Tropyl tropate
  • Eyesules
  • t-3-ylester
  • Tropine tropate
  • troyltropate
  • (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate
  • endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • [ "" ]
  • Atropen
  • dl-Tropyltropate
  • Troyl tropate
  • Isopto-atropine
  • Atropin [German]
  • Atropina [Italian]
  • (+-)-hyoscyamine
  • Tropine, tropate (ester)
  • (+-)-atropine
  • Tropic acid, ester with tropine
  • (+/-)-Atropine
  • Atropine sulfate
  • Atropine (USP)
  • Isopto Atropine
  • Tropic acid, 3-alpha-tropanyl ester
  • Atropt
  • DL-Tropanyl 2-hydroxy-1
  • (3-exo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl alpha-(hydroxymethyl)benzeneacetate
  • (3-endo,8-syn)-3-[(3-hydroxy-2-phenylpropanoyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane
  • Atropine [USP:BAN]
  • ATROPINE [VANDF]
  • BCP15060
  • Atropine for peak identification, European Pharmacopoeia (EP) Reference Standard
  • AI3-60219
  • Peptard
  • (3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL TROPATE
  • Anaspaz (TN)
  • Atropine, >=95.0% (NT)
  • Atropine, >=99% (TLC), powder
  • beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester
  • OR22908
  • Opera_ID_1088
  • MEGxp0_001878
  • Tropine (+/-)-tropate
  • dl-Hyoscyamine
  • Tropic acid, (-)-, ester with tropine
  • NCGC00017333-03
  • Minims
  • EINECS 202-933-0
  • BRN 0091258
  • Atropair
  • Levsin SL
  • C01479
  • Tropine, (-)-tropate
  • Hyocyamine
  • Levsin (TN)
  • DB00572
  • 5908-99-6
  • Atropine, meets USP testing specifications
  • Atropine, 3(S)-endo-Isomer
  • Atropine, analytical standard
  • atropinum sulphuricum
  • ATROPINE COMPONENT OF DUODOTE
  • Hyoscyamine, l-
  • tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
  • Cystospaz
  • Hyoscyamine (USP)
  • 51-55-8
  • ATNAA COMPONENT ATROPINE
  • HSDB 3552
  • Tox21_110816
  • a-Tropine
  • rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
  • DTXSID601141720
  • Atropine Care
  • Levsinex SR
  • Benzeneacetic acid, .alpha.-(hydroxymethyl)-, endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)-
  • C17H23NO3
  • NP-010662
  • CHEMBL254656
  • Gastrosed
  • NC00493
  • CHEBI:16684
  • ATROPINE, (+/-)-
  • Hyospaz
  • hyoscyamine
  • 1-Hyoscyamine
  • ATROPINE [WHO-DD]
  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester)
  • 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester)
  • Cytospaz
  • RKUNBYITZUJHSG-SPUOUPEWSA-N
  • Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-
  • Symax SR
  • HMS2231G17
  • Benzeneacetic acid, .alpha.-(hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(.+-.)-
  • EINECS 200-104-8
  • (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
  • Ocu-Tropine
  • alpha-(Hydroxymethyl)benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • AB00694549-12
  • Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl ester, endo-(+-)-
  • ATROPINE [EP MONOGRAPH]
  • AS-56020
  • Atropinum
  • FT-0627165
  • Buwecon
  • Levsin
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (3(R)-endo)-
  • Tropine tropate
  • DL-Hyoscyamine
  • atropinium cation
  • Minims Atropine
  • SMR000058248
  • s4713
  • ATROPINE [GREEN BOOK]
  • CHEMBL517712
  • NCGC00159345-02
  • R-(+)-Hyoscyamine
  • Atropen (TN)
  • Cystospaz (TN)
  • NCGC00258041-01
  • 3-tropoyloxytropane
  • BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-(3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER
  • Buwecon (TN)
  • 1alphaH,5alphaH-Tropan-3alpha-ol (-)-tropate (ester)
  • Atropine, European Pharmacopoeia (EP) Reference Standard
  • CAS-51-55-8
  • ATROPINE [USP-RS]
  • rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(+-)-
  • DL-Tropanyl 2-hydroxy-1-phenylpropionate
  • 8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate
  • CS-4834
  • ATROPINE [MART.]
  • Q26272
  • (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
  • NuLev (TN)
  • D00113
  • ATROPINE ((+/-)-)
  • beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]
  • L-Hyoscamine
  • [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate
  • Atropine ((+/-)-Hyoscyamin)
  • HMS2089A16
  • D0RG3O
  • UNII-7C0697DR9I
  • Atropine sulfate hydrate
  • Benzeneacetic acid, .alpha.-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(S)-endo]-
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate
  • BRD-A27290375-330-01-1
  • Hyospasmol (TN)
  • Atropine [BAN]
  • Atropine Sulfate S.O.P.
  • 1-alpha H,5-alpha H-tropan-3-alpha-ol (+-)-tropate (ester)
  • OIN
  • DTXCID20113
  • 1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (+/-)-TROPATE (ESTER)
  • BDBM200229
  • Belladenal
  • AB00694549-11
  • Donnamar
  • [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate
  • BDBM50403547
  • NCGC00017333-02
  • GTPL320
  • [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
  • NCGC00142514-03
  • beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]
  • Atrosulf
  • C1504
  • NCGC00142514-01
  • cid_174174
  • Hyoscyamine (D)-
  • LS-7203
  • alpha-Hydroxymethylphenylacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octane-3-yl ester
  • HSDB 3553
  • atropinium(1+)
  • AKOS015955538
  • NCGC00017333-04
  • AB00694549_14
  • (1beta,3alpha,5beta)-3-[(3-Hydroxy-1-oxo-2-phenylpropyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane
  • Hyoscyamine [BAN]
  • D0RD5W
  • l-Atropine
  • b eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • ATROPINE [USP MONOGRAPH]
  • HY-B1205
  • Hyosyne
  • l-Hyopscyamine
  • ropine tropate
  • 7C0697DR9I
  • Benzeneacetic acid, alpha-(hydroxymethyl)- 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester endo-(+-)-
  • HMS3259M13
  • NCGC00017333-06
  • MLS001148094
  • CHEMBL475124
  • CHEBI:78734
  • Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
  • HSDB 2199
  • Donnamar (TN)
  • Symax Duotab
  • NCGC00017333-05
  • BRD-A27290375-001-01-8
  • Protamine & Atropine
  • Neo-Diophen
  • ATROPINE [MI]
  • (+/-)-Hyoscyamine
  • Symax SL
  • bmse000649
  • ATROPINE [ORANGE BOOK]
  • DUODOTE COMPONENT ATROPINE
  • L-Hyoscyamine
  • Tropine, (-)-tropate (ester)
  • SCHEMBL2812
  • NCGC00385525-01
  • HOMATROPINE HYDROBROMIDE IMPURITY D [EP IMPURITY]
  • ATROPINE COMPONENT OF ATNAA
  • BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-
  • ATROPINE [EP IMPURITY]
  • Neoquess (TN)
  • (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate
  • CCRIS 3080
  • DTXSID4020113
  • ACon1_000046
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
  • Tox21_111590
  • 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
  • Hyoscyamine sulfate
  • MLS002695888
  • (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+/-)-
  • Urised
  • 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate
  • d1-hyoscyamine
  • Symax (TN)
  • beta-Phenyl-gamma-oxypropionsaure-tropyl-ester
  • (alpha S)-alpha-(Hydroxymethyl)benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • Symax
  • (-)-Tropic Acid Ester with Tropine
  • I-Tropine
  • H 9002
  • Tox21_200487
  • HyoMax (TN)
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-
  • Levbid (TN)
  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI)
  • ATROPINUM [HPUS]
  • Levbid
  • 16175-85-2
  • MLS000069795
  • DL-Hyoscyamine
  • Atropine
  • MFCD00022622
  • Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo [3.2.1]oct-3-yl ester, endo-(+/-)-
  • SCHEMBL26698079
物化性质
实验特性
LogP 1.86880
PSA 49.77000
Merck 875
折射率 1.581
沸点 429.8°C at 760 mmHg
熔点 115-118?°C
蒸气压 0mmHg at 25°C
闪点 213.7°C
溶解度 H2O: 2 mg/mL
颜色与性状 粉末
溶解性 1g溶于455ml水、90ml80℃水、2ml乙醇、1.2ml60℃乙醇、27ml甘油、25ml乙醚和1ml氯仿,也溶于苯和稀酸。0.0015mol/L溶液的pH为10.0
Fluka 8-10-23
敏感性 Light Sensitive
酸度系数(pKa) 9.7(at 21℃)
密度 1.19 g/cm3
计算特性
精确分子量 289.16800
氢键供体数量 1
氢键受体数量 4
可旋转化学键数量 5
同位素质量 289.168
重原子数量 21
复杂度 353
同位素原子数量 0
确定原子立构中心数量 2
不确定原子立构中心数量 1
确定化学键立构中心数量 0
不确定化学键立构中心数量 0
共价键单元数量 1
疏水参数计算参考值(XlogP) 1.8
表面电荷 0
拓扑分子极性表面积 49.8
国际标准相关数据
EINECS 3080
海关数据
海关编码 2939999090
海关数据

中国海关编码:

2939999090
生产方法和用途
方法
颠茄叶经提取莨菪碱(左旋体),再经消旋化、重结晶精制而得。
可从茄科东莨菪属植物唐古特山莨菪或喜马拉雅山莨菪的根中提取,也可以人工合成得到。
阿托品主要用于内脏平滑肌痉挛所致的绞痛(以缓解胃肠道平滑肌痉挛的效果较好),0.3mg口服或0.5mg皮下、肌内或静注;虹膜睫状体炎:0.5~1%液滴眼;全身麻醉前给药,以减少呼吸道及唾液分泌,0.5mg皮下注射;锑剂中毒所致的阿斯综合征:2mg静注及1~2mg皮下注射,以后每半小时静注1mg,病情好转后改用每2~4小时肌注1mg,直到心率达每分钟100次并恢复节律性心律;房室传导阻滞:0.5~1mg静注,每4~6小时一次;感染中毒性休克:在补充血容量前提下,1~2mg用葡萄糖液稀释后静注,每10~20分钟一次;有机磷酸酯类中毒:轻度中毒者0.5~1mg肌注,每日3次;中度中毒者1~2mg肌注或静注,每0.5~2小时一次;重度中毒者则1~3mg,每15~30分钟静注或肌注一次。青光眼和眼内压升高倾向、胃幽门梗阻和前列腺肥大的患者禁用阿托品。
用途
临床作为解痉药物,并作为检定金的试剂。
阿托品是副交感神经抑制剂,可作眼科的扩瞳剂、泻药;可缓减干草热、伤风鼻阻和肠痉挛;可用于治疗小儿夜尿症,有时用于舒减输尿管和胆道痉挛;还可用于治疗有机磷引起的中毒,作为抗胆碱药,阿托品的多方面药理作用,不利于其临床应用。现已陆续合成了一些具有专一作用的代用品,例如作为扩瞳剂的后马托品。阿托品毒性较大,剂量过大时可引起视觉模糊、分泌闭止、血管扩张、高热、兴奋、激动和谵妄。它是**、毛果芸香碱、毒扁豆碱等的拮抗剂。
生产方法 颠茄叶经提取莨菪碱(左旋体),再经消旋化、重结晶精制而得。也可以人工合成得到。
相关文献
专业数据库参考
PubChemId 24890401
参考资料
Beilstein 91260
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