名称和标识符别名信息物化性质安全信息海关数据生产方法和用途相关文献专业数据库参考相关产品

奥普力农 | 106730-54-5

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中文名称：奥普力农

英文名称： Olprinone

CAS No.： 106730-54-5

分子式： C₁₄H₁₀N₄O

分子量： 250.2554

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：奥普力农结构式

MSDS：奥普力农MSDS

PubChem CID： 4593

价格行情：奥普力农价格

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奥普力农的其他展现形式

相关化合物

3-Pyridinecarbonitrile,1,2-dihydro-6-methyl-5-(2-methylimidazo[1,2-a]pyridin-6-yl)-2-oxo-

CAS No.：106730-60-3
3-Pyridinecarboxamide,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-

CAS No.：106730-62-5
3-Pyridinecarbonitrile,1,2-dihydro-6-methyl-5-(7-methylimidazo[1,2-a]pyridin-6-yl)-2-oxo-

CAS No.：106730-58-9

名称和标识符

MDL	MFCD25541649
InChIKey	JPAWFIIYTJQOKW-UHFFFAOYSA-N
Inchi	1S/C14H10N4O/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10/h2-6,8H,1H3,(H,17,19)
SMILES	O=C1C(C#N)=C([H])C(=C(C([H])([H])[H])N1[H])C1C([H])=C([H])C2=NC([H])=C([H])N2C=1[H]

别名信息

- 中文别名 -

奥普力农
1,2-二氢-5-咪唑并[1,2-a]吡啶-6-基-6-甲基-2-氧代-3-吡啶甲腈
1,2-二氢-5-嘧啶并[1,2-Α]吡啶-6-基-6-甲基-2-氧-3-吡啶腈
罗普瑞酮
超干氯化钆

帕洛诺司琼
盐酸奥普力农

- 英文别名 -

5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
1,2-dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile
5-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-3-yl)-6-methyl-2-oxo-1h-pyridine-3-carbonitrile
LOPRINONE
Olprinone(Loprinone)

1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile
Olprinone
3-Pyridinecarbonitrile, 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile
1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
Coretec
Olprinone [INN]
UNII-4Y8BMI9YGC
5-(Imidazo[1,2-a]pyridine-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-
4Y8BMI9YGC
C14H10N4O
Olprinone (INN)
1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridinecarbonitrile
JPAWFIIYTJQOKW-UHFFFAOYSA-N
BCP09781
3950AH
NCGC0
DTXSID1048461
1,2-dihydro-5-(imidazo[1,2-a]-pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile
BRD-K20745393-001-01-4
OLPRINONE [WHO-DD]
NCGC00162385-01
SDCCGSBI-0633821.P001
LOPRINONE [MI]
1,2-Dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile.
1,2-dihydro-6-methyl-5-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-3-pyridinecarbonitrile
NCGC00162385-05
4606A
SCHEMBL27661
loprinone
AC-35198
AS-73630
NCGC00162385-03
NS00126108
D08294
CCG-266964
CHEBI:135019
NCGC00162385-02
5-{imidazo[1,2-a]pyridin-6-yl}-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
CHEMBL1474900
1,2-Dihydro-5-imidazo(1,2-alpha)pyridin-6-yl-6-methyl-2-oxonicotinonitrile
1,2-DIHYDRO-5-IMIDAZO(1,2-.ALPHA.)PYRIDIN-6-YL-6-METHYL-2-OXONICOTINONITRILE
s5539
1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile
NCGC00162385-10
CS-1190
Q7088538
HY-14254A
106730-54-5
AKOS022179657
C71263
FT-0631041

物化性质

实验特性

LogP	1.86968
PSA	73.95000
折射率	1.702
沸点	No data available
熔点	>300°
闪点	No data available
颜色与性状	从二甲基甲酰胺结晶。
密度	1.3±0.1 g/cm3

计算特性

精确分子量	250.08500
氢键供体数量	1
氢键受体数量	3
可旋转化学键数量	1
同位素质量	250.085
重原子数量	19
复杂度	525
同位素原子数量	0
确定原子立构中心数量	0
不确定原子立构中心数量	0
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	1
疏水参数计算参考值（XlogP）	1.5
互变异构体数量	5
表面电荷	0
拓扑分子极性表面积	70.2

安全信息

RTECS号	AK5110000
WGK Germany	3
安全术语	8
安全说明	S26; S36; S45; S61
包装等级	II
风险术语	R25; R34; R51/53; R24/25; R36
危险品标志	T N C
危险品运输编号	UN 2922 8/PG 2
危害声明	H302-H315-H319-H335
警示性声明	P261-P305+P351+P338
储存条件	Please store the product under the recommended conditions in the Certificate of Analysis.
信号词	Warning

海关数据

海关编码	29183000
海关数据	中国海关编码： 2933990090 概述： 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% 申报要素：品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 Summary： 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

海关编码

29183000

海关数据

中国海关编码：

2933990090

概述：

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

Summary：

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

生产方法和用途

用途	用于治疗急性心肌能不全。
生产方法	4-(二甲氨基)-3-(嘧啶并吡啶-6 -基)-3-丁烯-2-酮和氰乙酰胺在二甲基甲酰胺中,于80~90℃加热12h,得到奥普力农。

相关文献

1. Fe–SBA-15 catalyzed synthesis of 2-alkoxyimidazo[1,2-a]pyridines and screening of their in silico selectivity and binding affinity to biological targets
Soumen Payra,Arijit Saha,Chia-Ming Wu,Balaranjan Selvaratnam,Thorn Dramstad,Luther Mahoney,Sant Kumar Verma,Suresh Thareja,Ranjit Koodali,Subhash Banerjee New J. Chem. 2016 40 9753
2. Domino-synthesis and fluorescence properties of 4-cyano-2-oxo-1,2-dihydropyridine-3-carboxamides and 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles
O. V. Ershov,S. V. Fedoseev,M. Yu. Belikov,M. Yu. Ievlev RSC Adv. 2015 5 34191
3. Palladium(ii)-catalyzed intermolecular oxidative C-3 alkenylations of imidazo[1,2-a]pyridines by substrate-contolled regioselective C–H functionalization
Hua Cao,Sai Lei,Jinqiang Liao,Jianping Huang,Huifang Qiu,Qinlin Chen,Shuxian Qiu,Yaoyi Chen RSC Adv. 2014 4 50137
4. Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem
Shucheng Wang,Xuhu Huang,Zemei Ge,Xin Wang,Runtao Li RSC Adv. 2016 6 63532
5. Metal-free synthesis of imidazopyridine from nitroalkene and 2-aminopyridine in the presence of a catalytic amount of iodine and aqueous hydrogen peroxide
Yuma Tachikawa,Yoshitomo Nagasawa,Sohei Furuhashi,Lei Cui,Eiji Yamaguchi,Norihiro Tada,Tsuyoshi Miura,Akichika Itoh RSC Adv. 2015 5 9591
6. One pot synthesis of substituted imidazopyridines and thiazoles from styrenes in water assisted by NBS
Mahesh H. Shinde,Umesh A. Kshirsagar Green Chem. 2016 18 1455
7. Regioselective synthesis of unsymmetrical biheteroaryls via copper(ii)-catalyzed cascade annulation
Sadhanendu Samanta,Alakananda Hajra Chem. Commun. 2018 54 3379
8. Cu-Catalyzed selective C3-formylation of imidazo[1,2-a]pyridine C–H bonds with DMSO using molecular oxygen
Hua Cao,Sai Lei,Naiying Li,Longbin Chen,Jingyun Liu,Huiyin Cai,Shuxian Qiu,Jingwen Tan Chem. Commun. 2015 51 1823
9. I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines
Yimiao He,Wenqing Yin,Jian Wang,Jianrong Huang,Xinru Pang,Chunfang Gan,Fang Yang,Chusheng Huang Org. Chem. Front. 2018 5 1772
10. I2-catalyzed intramolecular oxidative amination of C(sp3)–H bond: efficient access to 3-acylimidazo[1,2-a]pyridines under neat condition
Lilan Huang,Wenqing Yin,Jian Wang,Chunfang Gan,Yanmin Huang,Chusheng Huang,Yimiao He RSC Adv. 2019 9 2381

专业数据库参考

PubChemId	4593

奥普力农 | 106730-54-5

中国海关编码：

概述：

申报要素：

Summary：

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