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格列本脲 | 10238-21-8

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中文名称：格列本脲

英文名称： Glibenclamide

CAS No.： 10238-21-8

分子式： C₂₃H₂₈ClN₃O₅S

分子量： 494.0035

如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击：格列本脲结构式

MSDS：格列本脲MSDS

PubChem CID： 3488

价格行情：格列本脲价格

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格列本脲的其他展现形式

相关杂质/同位素
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简介

格列苯脲（INN），又名优降糖（USAN），是一种磺酰脲类降糖药。市面上也可买到它与甲福明二甲双胍制成的合剂，名为 Glucovance
。格列本脲通过增加门静脉胰岛素水平或对肝脏直接作用，抑制肝糖原分解和糖原异生作用，肝生成和输出葡萄糖减少；口服吸收快，蛋白结合率很高，为95%，口服后2～5小时血药浓度达峰值，持续作用24小时。T1/2为10小时。在肝内代谢，由肝和肾排出各约50%。

名称和标识符

MDL	MFCD00056625
InChIKey	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Inchi	1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
SMILES	ClC1C([H])=C([H])C(=C(C=1[H])C(N([H])C([H])([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])S(N([H])C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O)(=O)=O)=O)OC([H])([H])[H]

别名信息

- 中文别名 -

格列本脲
N-[2-[4-[[[(环己氨基)羰基]氨基]磺酰基]苯基]乙基]-2-甲氧基-5-氯苯甲酰胺
5-氯-N-[2-[4-[[[(环己基氨基)羰基]氨基]磺酰基]苯基]乙基]-2-甲氧基苯甲酰胺
优降糖
格列呠咪

格列赫素
格列苯脲
Glibenclamide 格列本脲
N-(2-(4-((((环己氨基)羰基)氨基
氟氯西林钠
格列本脲 EP标准品
格列本脲标准品
格列本脲、格列苯脲
格列本脲-D3
格列本脲峰鉴别 EP标准品
格列苯脲标准品
金阳碱
优降糖 USP标准品
N-[2-[4-[[[(环己氨基)羰基]氨基]磺酰基]苯基]乙基]-2-甲氧基-5-氯苯甲
肌酸一水合物
一水肌酸
5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺
N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N′-环己基脲
5-氯-N-[4-(3-环己基脲基磺酰基)苯基乙基]-2-甲氧基苯甲酰胺
格列本脲(对照品)

- 英文别名 -

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide
Glibenclamide
Glybenzcyclamide
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)-phenethyl)-2-methoxybenzamide

GIBENCLAMIDE
GLYBENCLAMIDE
Glyburide
Glyburide (Glibenclamide)
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
[ "Glibenclamide" ]
Micronase
Diabeta
Glynase
Daonil
Euglucon
Maninil
Semi-daonil
Apo-Glibenclamide
Euglucon 5
Neogluconin
Bastiverit
Azuglucon
Renabetic
Prodiabet
Glucolon
Duraglucon
Orabetic
Euglykon
Euglucan
Yuglucon
Glibenil
Betanase
Benclamin
Tiabet
Libanil
Glibil
Glibens
Dibelet
Suraben
Humedia
Glimel
Glimide
Gilemal
Melix
Adiab
Pira
Med-Glionil
Normoglucon
Hexaglucon
Glucohexal
Glibenbeta
Praeciglucon
Lisaglucon
Gewaglucon
Glucoremed
Glibencla
NCGC00015467-06
NCGC00015467-06
Glyburide (USAN:USP)
Glyburide (USAN:USP)
A19539
A19539
Glibet
Glibet
HMS3712P14
HMS3712P14
Glibenclamid Heumann
Glibenclamid Heumann
Prestwick1_000316
Prestwick1_000316
UR 606
UR 606
GLYBURIDE COMPONENT OF GLUCOVANCE
GLYBURIDE COMPONENT OF GLUCOVANCE
Glibenclamida
Glibenclamida
Debtan
Debtan
4-(2-(5-Chloro-2-methoxybenzoylamino)ethyl)-N-(cyclohexylcarbamoyl)benzenesulfonamide
4-(2-(5-Chloro-2-methoxybenzoylamino)ethyl)-N-(cyclohexylcarbamoyl)benzenesulfonamide
GLYBURIDE (USP-RS)
GLYBURIDE (USP-RS)
Semi-Euglucon
Semi-Euglucon
N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N'-cyclohexylurea
Tox21_110158_1
Tox21_110158_1
Glucoven
Glucoven
Micronized glyburide
Micronized glyburide
Prestwick2_000316
Prestwick2_000316
1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea
1-[[p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea
EN300-117270
EN300-117270
AB00051949-16
AB00051949-16
Glibenclamid Riker M.
Glibenclamid Riker M.
C23H28ClN3O5S
C23H28ClN3O5S
KBioSS_000071
KBioSS_000071
MLS001077262
MLS001077262
Gliben
Gliben
SMR000058229
SMR000058229
NCGC00015467-08
NCGC00015467-08
Euclamin
Euclamin
Glibenclamida (INN-Spanish)
Glibenclamida (INN-Spanish)
BSPBio_001351
BSPBio_001351
HMS2089L06
HMS2089L06
GLYBURIDE [USP-RS]
GLYBURIDE [USP-RS]
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea
SPBio_001831
SPBio_001831
Glybenclamide, European Pharmacopoeia (EP) Reference Standard
Glybenclamide, European Pharmacopoeia (EP) Reference Standard
CCG-39618
CCG-39618
Prestwick_569
Prestwick_569
RP-1127
RP-1127
BRD-K36927236-001-06-0
BRD-K36927236-001-06-0
Cytagon
Cytagon
NCGC00015467-07
NCGC00015467-07
KBioGR_000071
KBioGR_000071
BG166164
BG166164
Lopac0_000499
Lopac0_000499
Glibenclamide for peak identification
Glibenclamide for peak identification
SY057080
SY057080
S1716
S1716
5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide
5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide
GLYBURIDE [USP MONOGRAPH]
GLYBURIDE [USP MONOGRAPH]
Glibenclamid AL
Glibenclamid AL
1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea
1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea
1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea
1-{4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonyl}-3-cyclohexylurea
Glibesyn
Glibesyn
Glamide
Glamide
Glibadone
Glibadone
HMS3675F16
HMS3675F16
NSC-759618
NSC-759618
NCGC00015467-01
NCGC00015467-01
Spectrum2_001816
Spectrum2_001816
Tocris-0911
Tocris-0911
Glyburide [USAN:USP]
Glyburide [USAN:USP]
SR-01000000196
SR-01000000196
Lopac-G-0639
Lopac-G-0639
SBI-0050483.P003
SBI-0050483.P003
Calabren
Calabren
5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
NCGC00015467-04
NCGC00015467-04
GLIBENCLAMIDE [WHO-DD]
GLIBENCLAMIDE [WHO-DD]
Tox21_110158
Tox21_110158
GTPL2414
GTPL2414
FT-0601608
FT-0601608
Glyburide (micronized)
Glyburide (micronized)
NSC 759618
NSC 759618
Glibenclamide - Bio-X
Glibenclamide - Bio-X
NCGC00016689-01
NCGC00016689-01
NCGC00015467-15
NCGC00015467-15
Sugril
Sugril
AB00051949
AB00051949
CHEMBL472
CHEMBL472
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
Glibenclamide (JP17/INN)
Glibenclamide (JP17/INN)
HMS1791D13
HMS1791D13
NCGC00015467-16
NCGC00015467-16
Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-
Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-
NCGC00015467-14
NCGC00015467-14
KBio2_002639
KBio2_002639
Glybenclamide
Glybenclamide
Glibenclamid Basics
Glibenclamid Basics
SR-01000000196-6
SR-01000000196-6
HD 419
HD 419
BCP05327
BCP05327
glyburide
glyburide
Delmide
Delmide
NCGC00015467-18
NCGC00015467-18
GLYBURIDE [ORANGE BOOK]
GLYBURIDE [ORANGE BOOK]
Gluben
Gluben
Glitisol
Glitisol
Glibenclamidum
Glibenclamidum
DTXSID0037237
DTXSID0037237
HMS3411F16
HMS3411F16
HB-419
HB-419
Glibenclamide 1.0 mg/ml in Acetonitrile
Glibenclamide 1.0 mg/ml in Acetonitrile
HMS1361D13
HMS1361D13
Spectrum5_001631
Spectrum5_001631
Glyburide, United States Pharmacopeia (USP) Reference Standard
Glyburide, United States Pharmacopeia (USP) Reference Standard
GBM
GBM
N1-[4-({[(cyclohexylamino)carbonyl]amino}sulfonyl)phenethyl]-5-chloro-2-methoxybenzamide
N1-[4-({[(cyclohexylamino)carbonyl]amino}sulfonyl)phenethyl]-5-chloro-2-methoxybenzamide
DTXCID8017237
DTXCID8017237
GLIBENCLAMIDE [MART.]
GLIBENCLAMIDE [MART.]
Bio2_000071
Bio2_000071
5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide
CS-1075
CS-1075
SR-01000000196-5
SR-01000000196-5
Norglicem 5
Norglicem 5
Bio1_000076
Bio1_000076
BCP9000729
BCP9000729
Glucobene
Glucobene
HMS1568P14
HMS1568P14
KBio3_002273
KBio3_002273
HB 419
HB 419
CAS-10238-21-8
CAS-10238-21-8
Prestwick0_000316
Prestwick0_000316
BSPBio_003053
BSPBio_003053
AKOS001487495
AKOS001487495
GLIBENCLAMIDE [JAN]
GLIBENCLAMIDE [JAN]
LP00499
LP00499
Gliboral
Gliboral
N-(4-(.beta.-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
N-(4-(.beta.-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
NCGC00015467-11
NCGC00015467-11
Glucomid
Glucomid
Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard
Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard
Certified Reference Material
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard
Certified Reference Material
Glubate
Glubate
U-26,45
U-26,45
U-26,452
U-26,452
Glycomin
Glycomin
NCGC00015467-37
NCGC00015467-37
Semi-Gliben-Puren N
Semi-Gliben-Puren N
GLYBURIDE [VANDF]
GLYBURIDE [VANDF]
NCGC00015467-02
NCGC00015467-02
BRN 2230085
BRN 2230085
Glyburide - CAS 10238-21-8
Glyburide - CAS 10238-21-8
NCGC00015467-13
NCGC00015467-13
SX6K58TVWC
SX6K58TVWC
GLIBENCLAMIDE [EP MONOGRAPH]
GLIBENCLAMIDE [EP MONOGRAPH]
KBioSS_000730
KBioSS_000730
KBio2_000730
KBio2_000730
Glibenclamid-Cophar
Glibenclamid-Cophar
D81733
D81733
W-108874
W-108874
HMS2095P14
HMS2095P14
GLUCOVANCE COMPONENT GLYBURIDE
GLUCOVANCE COMPONENT GLYBURIDE
NCGC00261184-01
NCGC00261184-01
Glyben
Glyben
5-Chloro-N-(2-[4-(([(cyclohexylamino)carbonyl]amino)sulfonyl)phenyl]ethyl)-2-methoxybenzamide #
5-Chloro-N-(2-[4-(([(cyclohexylamino)carbonyl]amino)sulfonyl)phenyl]ethyl)-2-methoxybenzamide #
Glyburide [USAN]
Glyburide [USAN]
Spectrum3_001327
Spectrum3_001327
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
HMS2093P04
HMS2093P04
Cirara
Cirara
Nadib
Nadib
GLIBENCLAMIDE (MART.)
GLIBENCLAMIDE (MART.)
SDCCGSBI-0050483.P004
SDCCGSBI-0050483.P004
NCGC00023447-07
NCGC00023447-07
Oprea1_764617
Oprea1_764617
Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
Hemi-Daonil
Hemi-Daonil
NCGC00023447-04
NCGC00023447-04
U 26452
U 26452
Amglidia
Amglidia
Novo-Glyburide
Novo-Glyburide
GLYBURIDE (USP MONOGRAPH)
GLYBURIDE (USP MONOGRAPH)
Bio1_001054
Bio1_001054
NCGC00015467-17
NCGC00015467-17
Glybenzcyclamide, 99%
Glybenzcyclamide, 99%
5-chloro-N-(2-(4-(N-(N-cyclohexylcarbamoyl)sulfamoyl)phenyl)ethyl)-2-methoxybenzamide
5-chloro-N-(2-(4-(N-(N-cyclohexylcarbamoyl)sulfamoyl)phenyl)ethyl)-2-methoxybenzamide
BRD-K36927236-001-17-7
BRD-K36927236-001-17-7
Glibenclamide,(S)
Glibenclamide,(S)
NCGC00023447-12
NCGC00023447-12
NCGC00254662-01
NCGC00254662-01
GLYBURIDE [WHO-IP]
GLYBURIDE [WHO-IP]
Glibetic
Glibetic
U-26452
U-26452
Opera_ID_801
Opera_ID_801
Glibenclamidum (INN-Latin)
Glibenclamidum (INN-Latin)
Micronase (TN)
Micronase (TN)
Gen-Glybe
Gen-Glybe
HMS3651E17
HMS3651E17
NCGC00023447-02
NCGC00023447-02
GLIBENCLAMIDUM [WHO-IP LATIN]
GLIBENCLAMIDUM [WHO-IP LATIN]
Glyburide (USP)
Glyburide (USP)
KBio2_003298
KBio2_003298
Glisulin
Glisulin
NCGC00015467-21
NCGC00015467-21
Bio2_000551
Bio2_000551
NCGC00023447-09
NCGC00023447-09
G0382
G0382
Glibenclamide
Glyburide
Glibenclamide
Glyburide
5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide
5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide
AB00051949_19
AB00051949_19
NCGC00023447-11
NCGC00023447-11
Abbenclamide
Abbenclamide
SR-01000000196-2
SR-01000000196-2
Miglucan
Miglucan
Diabeta (TN)
Diabeta (TN)
BDBM50012957
BDBM50012957
NCGC00023447-05
NCGC00023447-05
NCGC00015467-36
NCGC00015467-36
NCGC00023447-06
NCGC00023447-06
KBio2_005207
KBio2_005207
NCGC00023447-08
NCGC00023447-08
Lederglib
Lederglib
Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
NCGC00015467-12
NCGC00015467-12
HY-15206
HY-15206
C07022
C07022
NSC-813214
NSC-813214
D00336
D00336
GBN 5
GBN 5
KBio1_000481
KBio1_000481
KBio3_000141
KBio3_000141
SCHEMBL22009
SCHEMBL22009
NS00001144
NS00001144
HMS3261D19
HMS3261D19
Glibenclamid-Ratiopharm
Glibenclamid-Ratiopharm
Glibenclamide [INN]
Glibenclamide [INN]
Spectrum_000250
Spectrum_000250
CHEBI:5441
CHEBI:5441
Gliban
Gliban
glyburide (glibenclamide)
glyburide (glibenclamide)
IDI1_000481
IDI1_000481
Q420626
Q420626
DivK1c_000481
DivK1c_000481
Probes1_000431
Probes1_000431
SPECTRUM2300229
SPECTRUM2300229
GLYBURIDE [MI]
GLYBURIDE [MI]
MLS000069721
MLS000069721
Prestwick3_000316
Prestwick3_000316
G 0639
G 0639
AB00051949-17
AB00051949-17
BSPBio_000312
BSPBio_000312
5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
GLIBENCLAMIDE [WHO-IP]
GLIBENCLAMIDE [WHO-IP]
EU-0100499
EU-0100499
SR-01000000196-4
SR-01000000196-4
GLIBENCLAMIDE (EP MONOGRAPH)
GLIBENCLAMIDE (EP MONOGRAPH)
Glibenclamidum [INN-Latin]
Glibenclamidum [INN-Latin]
Glybenclamide, >=99% (HPLC)
Glybenclamide, >=99% (HPLC)
Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-
Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy-
10238-21-8
10238-21-8
NCGC00015467-05
NCGC00015467-05
KBioGR_001897
KBioGR_001897
Glycron
Glycron
UPCMLD-DP006
UPCMLD-DP006
KBio3_000142
KBio3_000142
Probes2_000378
Probes2_000378
M01823
M01823
DB01016
DB01016
Betanese 5
Betanese 5
HMS3402D13
HMS3402D13
CBiol_001790
CBiol_001790
Glicem
Glicem
KBio2_000071
KBio2_000071
KS-5326
KS-5326
MFCD00056625
MFCD00056625
HMS1922L08
HMS1922L08
HMS1989D13
HMS1989D13
Glibenclamida [INN-Spanish]
Glibenclamida [INN-Spanish]
NCGC00023447-10
NCGC00023447-10
Glidiabet
Glidiabet
UNII-SX6K58TVWC
UNII-SX6K58TVWC
NSC813214
NSC813214
Diabiphage
Diabiphage
BPBio1_000344
BPBio1_000344
Tox21_500499
Tox21_500499
NCGC00015467-03
NCGC00015467-03
NCGC00015467-20
NCGC00015467-20
NSC759618
NSC759618
UPCMLD-DP006:001
UPCMLD-DP006:001
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea
AB00051949_18
AB00051949_18
IDI1_033821
IDI1_033821
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
NCGC00015467-10
NCGC00015467-10
SPBio_002531
SPBio_002531
Glynase (TN)
Glynase (TN)
Bio1_000565
Bio1_000565
KBio2_005866
KBio2_005866
NINDS_000481
NINDS_000481
NC00566
NC00566
EINECS 233-570-6
EINECS 233-570-6
Z277540138
Z277540138
SB17414
SB17414
BIDD:GT0239
BIDD:GT0239
Glibenclamid Genericon
Glibenclamid Genericon
Glyburide, meets USP testing specifications
Glyburide, meets USP testing specifications
HMS3428D15
HMS3428D15
HMS3267A15
HMS3267A15
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
Pharmakon1600-02300229
Pharmakon1600-02300229
SR-01000000196-8
SR-01000000196-8
5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
A10BB01
A10BB01
NCGC00015467-09
NCGC00015467-09
SW195828-5
SW195828-5
HMS3259O12
HMS3259O12
Tox21_300758
Tox21_300758
HMS501I03
HMS501I03
Glibenclamid Fabra
Glibenclamid Fabra
Spectrum4_001199
Spectrum4_001199
Glyburide/Gliebenclamide

物化性质

实验特性

LogP	5.89520
PSA	121.98000
Merck	4478
折射率	1.6100 (estimate)
水溶性	Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.
沸点	°Cat760mmHg
熔点	172.0 to 176.0 deg-C
闪点	°C
溶解度	ethanol: soluble2mg/mL
颜色与性状	Powder
溶解性	不溶于水，微溶于乙醇，丙酮，氯仿。
酸度系数(pKa)	5.3(at 25℃)
密度	1.1805 (rough estimate)

计算特性

精确分子量	493.14400
氢键供体数量	3
氢键受体数量	5
可旋转化学键数量	8
同位素质量	493.143819
重原子数量	33
复杂度	746
同位素原子数量	0
确定原子立构中心数量	0
不确定原子立构中心数量	0
确定化学键立构中心数量	0
不确定化学键立构中心数量	0
共价键单元数量	1
疏水参数计算参考值（XlogP）	4.8
表面电荷	0
拓扑分子极性表面积	122

安全信息

RTECS号	YS4725200
WGK Germany	2
安全说明	S22-S36/37/39
风险术语	R20/21/22
危险品标志	Xn
危险品运输编号	NONH for all modes of transport
危害声明	H315; H319; H335
警示性声明	P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
储存条件	2-8°C
危险类别码	20/21/22
信号词	Warning
毒性	LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami)

国际标准相关数据

EINECS	233-570-6

海关数据

海关编码	2935009090
海关数据	中国海关编码： 2935009090 概述： 2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0% 申报要素：品名, 成分含量, 用途 Summary： 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

海关编码

2935009090

海关数据

中国海关编码：

2935009090

概述：

2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

申报要素：

品名, 成分含量, 用途

Summary：

2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

生产方法和用途

用途	降血糖。适用于单用饮食控制疗效不满意的轻、中度Ⅱ型糖尿病,病人胰岛β细胞有一定得分泌胰岛素功能,并且无严重的并发症。

格列本脲 | 10238-21-8

中国海关编码：

概述：

申报要素：

Summary：

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